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Effects of high flavanol dark chocolate on cardiovascular function and platelet aggregation

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dc.contributor.authorGurvinder Rullen_US
dc.contributor.authorZetty Nadia Mohd Zainen_US
dc.contributor.authorJulian Shielen_US
dc.contributor.authorMartina H. Lundbergen_US
dc.contributor.authorDavid J. Collieren_US
dc.contributor.authorAtholl Johnstonen_US
dc.contributor.authorTimothy D.Warneren_US
dc.contributor.authorRoger Corderen_US
dc.date.accessioned2024-05-28T06:13:25Z
dc.date.available2024-05-28T06:13:25Z
dc.date.issued2015
dc.descriptionVolume 71en_US
dc.description.abstractRegular consumption of chocolate and cocoa products has been linked to reduced cardiovascular mortality. This study compared the effects of high flavanol dark chocolate (HFDC; 1064 mg flavanols/day for 6 weeks) and low flavanol dark chocolate (LFDC; 88mg flavanols/day for 6 weeks) on blood pressure, heart rate, vascular function and platelet aggregation in men with pre-hypertension ormild hypertension. Vascular function was assessed by pulse wave analysis using radial artery applanation tonometry in combination with inhaled salbutamol (0.4 mg) to assess changes due to endothelium-dependent vasodilatation. HFDC did not significantly reduce blood pressure compared to baseline or LFDC. Heart rate was increased by LFDC compared to baseline, but not by HFDC. Vascular responses to salbutamol tended to be greater after HFDC. Platelet aggregation induced by collagen or the thromboxane analogue U46619 was unchanged after LFDC or HFDC, whereas both chocolates reduced responses to ADP and the thrombin receptor activator peptide, SFLLRNamide (TRAP6), relative to baseline. Pre-incubation of platelets with theobromine also attenuated platelet aggregation induced by ADP or TRAP6. We conclude that consumption ofHFDC confersmodest improvements in cardiovascular function. Platelet aggregation is modulated by a flavanol-independent mechanism that is likely due to theobromine.en_US
dc.identifier.doi10.1016/j.vph.2015.02.010
dc.identifier.epage78
dc.identifier.issn1537-1891
dc.identifier.other438-6
dc.identifier.spage70
dc.identifier.urihttps://oarep.usim.edu.my/handle/123456789/7181
dc.identifier.volume71
dc.language.isoen_USen_US
dc.publisherElselvieren_US
dc.relation.ispartofVascular Pharmacologyen_US
dc.subjectPlatelet; PDE inhibitor; Blood pressure; Heart rate; Pulse pressure amplification ratioen_US
dc.titleEffects of high flavanol dark chocolate on cardiovascular function and platelet aggregationen_US
dc.typeArticleen_US
dspace.entity.typePublication

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