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Thickened carotid intima media thickness and carotid atherosclerosis among lupus nephritis patients: The role of traditional and lupus-specific factors

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dc.Chemicals/CASC reactive protein, 9007-41-4; complement component C4, 80295-48-3, 80295-71-2; C-Reactive Protein, 9007-41-4; Complement C4
dc.citedby5
dc.contributor.affiliationsFaculty of Medicine and Health Sciences
dc.contributor.affiliationsUniversiti Kebangsaan Malaysia (UKM) Medical Centre
dc.contributor.affiliationsUniversiti Sains Islam Malaysia (USIM)
dc.contributor.affiliationsUniversiti Putra Malaysia (UPM)
dc.contributor.authorSazliyana S.en_US
dc.contributor.authorMohd Shahrir M.S.en_US
dc.contributor.authorKong N.C.T.en_US
dc.contributor.authorTan H.J.en_US
dc.contributor.authorHamidon B.B.en_US
dc.contributor.authorAzmi M.T.en_US
dc.date.accessioned2024-05-29T01:54:46Z
dc.date.available2024-05-29T01:54:46Z
dc.date.issued2011
dc.description.abstractAim: The objectives of this study were to investigate the frequency of thickened carotid intima media thickness (CIMT) and atherosclerosis among lupus nephritis (LN) patients and to study their associated risk factors. Method: In this cross-sectional study, carotid ultrasonography was performed on consecutive LN patients to determine CIMT and presence of carotid plaques. CIMT was considered to be abnormally thickened if it was more than the 75th percentile matched for age and sex from the 'Carotid Atherosclerosis Progression Study'. The association between thickened CIMT with traditional cardiovascular risk factors and lupus characteristics were examined. A total of 83 patients with the mean age of 33.6�10years were recruited. Results: Fourteen patients (16.9%) had thickened CIMT and three (3.6%) had carotid plaques. On univariate analysis, traditional risk factors significantly associated with thickened CIMT (P<0.05) were patient's current age, diabetes mellitus and waist circumference. Meanwhile, a lower serum C4 levels and higher serum C-reactive protein levels were the lupus-specific factors associated with thickened CIMT (P<0.05, P<0.05 and P<0.01, respectively). In logistic regression analysis, the independent predictors of thickened CIMT were age of diagnosis, lower serum C4 levels and waist circumference (P<0.05). Conclusion: More lupus specific factors were independently associated with thickened CIMT, suggesting that a multi-targeted approach of treatment addressing both the lupus and traditional cardiovascular risks are very important. Larger prospective studies of these special risk factors are indicated. � 2011 The Authors. International Journal of Rheumatic Diseases � 2011 Asia Pacific League of Associations for Rheumatology and Blackwell Publishing Asia Pty Ltd.en_US
dc.description.natureFinalen_US
dc.identifier.doi10.1111/j.1756-185X.2011.01638.x
dc.identifier.epage275
dc.identifier.issn17561841
dc.identifier.issue3
dc.identifier.pmid21816023
dc.identifier.scopus2-s2.0-79961132068
dc.identifier.spage267
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-79961132068&doi=10.1111%2fj.1756-185X.2011.01638.x&partnerID=40&md5=0fd464e9dd0f3bb19ed3b009e2c312bf
dc.identifier.urihttps://oarep.usim.edu.my/handle/123456789/9544
dc.identifier.volume14
dc.languageEnglish
dc.language.isoen_USen_US
dc.relation.ispartofInternational Journal of Rheumatic Diseases
dc.sourceScopus
dc.subjectCarotid intima media thickness (CIMT)en_US
dc.subjectLupus nephritisen_US
dc.subjectLupus specific risk factorsen_US
dc.subjectTraditional cardiovascular risk factorsen_US
dc.titleThickened carotid intima media thickness and carotid atherosclerosis among lupus nephritis patients: The role of traditional and lupus-specific factorsen_US
dc.title.alternativeInt. J. Rheum. Dis.en_US
dc.typeArticleen_US
dspace.entity.typePublication

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