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TREM-1 modulation produces positive outcome on the histopathology and cytokines release profile of Plasmodium berghei-infected mice

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dc.Chemicals/CASgamma interferon, 82115-62-6; hemozoin, 39404-00-7
dc.FundingDetails04-11-08-629FR Ministry of Higher Education, Malaysia
dc.FundingDetailsAcknowledgements We would like to acknowledge Universiti Putra Malaysia, Malaysia and Ministry of Education, Malaysia under Fundamental Research Grant Scheme (FRGS) (04-11-08-629FR) for providing financial and infrastructure support for the conduction of the research study.
dc.ManufacturersR and D Systems, United States
dc.TradenamesQuantikine, R and D Systems, United States
dc.contributor.affiliationsFaculty of Medicine and Health Sciences
dc.contributor.affiliationsUniversiti Putra Malaysia (UPM)
dc.contributor.affiliationsTaylor�s University
dc.contributor.affiliationsUniversiti Sains Islam Malaysia (USIM)
dc.contributor.authorChin V.K.en_US
dc.contributor.authorAsyran A.M.Y.en_US
dc.contributor.authorZakaria Z.A.en_US
dc.contributor.authorAbdullah W.O.en_US
dc.contributor.authorChong P.P.en_US
dc.contributor.authorNordin N.en_US
dc.contributor.authorIbraheem Z.O.en_US
dc.contributor.authorMajid R.A.en_US
dc.contributor.authorBasir R.en_US
dc.date.accessioned2024-05-28T08:38:56Z
dc.date.available2024-05-28T08:38:56Z
dc.date.issued2018-12-15
dc.descriptionJournal of Parasitic Diseases volume 43, pages139–153(2019)en_US
dc.description.abstractTriggering receptor expressed on myeloid cells 1 (TREM-1) is a potential molecular therapeutic target for various inflammatory diseases. Despite that, the role of TREM-1 during malaria pathogenesis remains obscure with present literature suggesting a link between TREM-1 with severe malaria development. Therefore, this study aims to investigate the role of TREM-1 and TREM-1 related drugs during severe malaria infection in Plasmodium berghei-infected mice model. Our findings revealed that TREM-1 concentration was significantly increased throughout the infection periods and TREM-1 was positively correlated with malaria parasitemia development. This suggests a positive involvement of TREM-1 in severe malaria development. Meanwhile, blocking of TREM-1 activation using rmTREM-1/Fc and TREM-1 clearance by mTREM-1/Ab had significantly reduced malaria parasitemia and suppressed the production of pro- inflammatory cytokines (TNF-?, IL-6 and IFN-?) and anti-inflammatory cytokine (IL-10). Furthermore, histopathological analysis of TREM-1 related drug treatments, in particular rmTREM-1/Fc showed significant improvements in the histological conditions of major organs (kidneys, spleen, lungs, liver and brain) of Plasmodium berghei-infected mice. This study showed that modulation of TREM-1 released during malaria infection produces a positive outcome on malaria infection through inhibition of pro-inflammatory cytokines secretion and alleviation of histopathological conditions of affected organs. Nevertheless, further investigation on its optimal dosage and dose dependant study should be carried out to maximise its full potential as immunomodulatory or as an adjuvant in line with current antimalarial agents. � 2018, Indian Society for Parasitology.en_US
dc.description.natureFinalen_US
dc.identifier.doi10.1007/s12639-018-1070-3
dc.identifier.epage153
dc.identifier.issn9717196
dc.identifier.issue1
dc.identifier.scopus2-s2.0-85058375478
dc.identifier.spage139
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85058375478&doi=10.1007%2fs12639-018-1070-3&partnerID=40&md5=53fb07b7e6a97497e224c2406e733a77
dc.identifier.urihttps://link.springer.com/article/10.1007/s12639-018-1070-3
dc.identifier.urihttps://oarep.usim.edu.my/handle/123456789/9228
dc.identifier.volume43
dc.languageEnglish
dc.language.isoen_USen_US
dc.publisherSpringeren_US
dc.relation.ispartofJournal of Parasitic Diseasesen_US
dc.sourceScopus
dc.subjectCytokinesen_US
dc.subjectExperimental malaria infectionen_US
dc.subjectHistopathologyen_US
dc.subjectTREM-1en_US
dc.subjectTREM-1 modulationen_US
dc.titleTREM-1 modulation produces positive outcome on the histopathology and cytokines release profile of Plasmodium berghei-infected miceen_US
dc.typeArticleen_US
dspace.entity.typePublication

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