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Antidiabetic and Hypolipidemic Activities of Curculigo Latifolia Fruit : Root Extract in High Fat Fed Diet and Low Dose STZ Induced Diabetic Rats

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dc.contributor.authorSiti Aisyah Abd Ghafaren_US
dc.contributor.authorNur Akmal Ishaken_US
dc.contributor.authorMaznah Ismailen_US
dc.contributor.authorMuhajir Hamiden_US
dc.contributor.authorZalinah Ahmaden_US
dc.date.accessioned2024-05-28T03:32:28Z
dc.date.available2024-05-28T03:32:28Z
dc.date.issued2013
dc.date.submitted--
dc.descriptionHindawi Publishing Corporation Evidence-Based Complementary and Alternative Medicine Volume 2013, Article ID 601838, 12 pagesen_US
dc.description.abstractCurculigo latifolia fruit is used as alternative sweetener while root is used as alternative treatment for diuretic and urinary problems. The antidiabetic and hypolipidemic activities of C. latifolia fruit:root aqueous extract in high fat diet (HFD) and 40 mg streptozotocin (STZ) induced diabetic rats through expression of genes involved in glucose and lipid metabolisms were investigated. Diabetic rats were treated with C. latifolia fruit:root extract for 4 weeks. Plasma glucose, insulin, adiponectin, lipid profiles, alanine aminotransferase (ALT), gamma glutamyltransferase (GGT), urea, and creatinine levels were measured before and after treatments. Regulations of selected genes involved in glucose and lipid metabolisms were determined. Results showed the significant (𝑃 < 0.05) increase in body weight, high density lipoprotein (HDL), insulin, and adiponectin levels and decreased glucose, total cholesterol (TC), triglycerides (TG), low density lipoprotein (LDL), urea, creatinine, ALT, and GGT levels in diabetic rats after 4 weeks treatment. Furthermore, C. latifolia fruit:root extract significantly increased the expression of IRS-1, IGF-1, GLUT4, PPAR𝛼, PPAR𝛾, AdipoR1, AdipoR2, leptin, LPL, and lipase genes in adipose and muscle tissues in diabetic rats. These results suggest that C. latifolia fruit:root extract exerts antidiabetic and hypolipidemic effects through altering regulation genes in glucose and lipid metabolisms in diabetic ratsen_US
dc.identifier.doihttp://dx.doi.org/10.1155/2013/601838
dc.identifier.epage12
dc.identifier.issn1741-4288
dc.identifier.spage1
dc.identifier.urihttps://www.hindawi.com/journals/ecam/2013/601838/
dc.identifier.urihttps://oarep.usim.edu.my/handle/123456789/4630
dc.identifier.volume2013
dc.language.isoen_USen_US
dc.publisherHindawien_US
dc.relation.ispartofEvidence-based Complementary and Alternative Medicineen_US
dc.titleAntidiabetic and Hypolipidemic Activities of Curculigo Latifolia Fruit : Root Extract in High Fat Fed Diet and Low Dose STZ Induced Diabetic Ratsen_US
dc.typeArticleen_US
dspace.entity.typePublication

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Antidiabetic and Hypolipidemic Activities of Curculigo latifolia Fruit:Root Extract in High Fat Fed Diet and Low Dose STZ Induced Diabetic Rats
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