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Modelling brain activations and connectivity of pain modulated by having a loved one nearby

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dc.Conferencecode137127
dc.Conferencedate7 November 2017 through 8 November 2017
dc.ConferencenameInternational Conference on Recent Advancements in Science and Technology 2017, ICoRAST 2017
dc.contributor.affiliationsFaculty of Science and Technology
dc.contributor.affiliationsUniversiti Sains Islam Malaysia (USIM)
dc.contributor.affiliationsUniversiti Sains Malaysia (USM)
dc.contributor.authorTamam S.en_US
dc.contributor.authorAhmad A.H.en_US
dc.contributor.authorKamil W.A.en_US
dc.date.accessioned2024-05-28T08:27:55Z
dc.date.available2024-05-28T08:27:55Z
dc.date.issued2018
dc.description.abstractThis study is to model the connectivity between activated areas in the brain associated with pain responses in the presence and absence of a loved one. We used Th:YAG laser targeted onto the dorsum of the right hand of 17 Malay-female participants (mean age 20.59; SD 2.85 years) in two conditions: (1) in the absence of a loved one in the functional magnetic resonance imaging (fMRI) room (Alone condition), and (2) in the presence of a loved one (Support condition). The laser-induced pain stimuli were delivered according to an fMRI paradigm utilising blocked design comprising 15 blocks of activity and 15 blocks of rest. Brain activations and connectivity were analysed using statistical parametric mapping (SPM), dynamic causal modelling (DCM) and Bayesian model selection (BMS) analyses. Individual responses to pain were found to be divided into two categories: (1) Love Hurts (participants who reported more pain in the presence of a loved one) involved activations in thalamus (THA), parahippocampal gyrus (PHG) and hippocampus (HIP); and (2) Love Heals (participants who reported less pain in the presence of a loved one) involved activations in all parts of cingulate cortex. BMS showed that Love Heals could be represented by a cortical network involving the area of anterior cingulate cortex (ACC), middle cingulate cortex (MCC) and posterior cingulate cortex (PCC) in the intrinsic connectivity of ACC ? PCC ? MCC and ACC ? MCC. There was no optimal model to explain the increase in pain threshold when accompanied by the loved one in Love Hurts. The present study reveals a new possible cortical network for the reduction of pain by having a loved one nearby.en_US
dc.description.natureFinalen_US
dc.editorAli E.S.Yatim N.M.Harun F.W.en_US
dc.identifier.doi10.1063/1.5041229
dc.identifier.isbn9780740000000
dc.identifier.issn0094243X
dc.identifier.scopus2-s2.0-85048877828
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85048877828&doi=10.1063%2f1.5041229&partnerID=40&md5=33ad59e98ec5d81e63e2180f3dca97fd
dc.identifier.urihttps://oarep.usim.edu.my/handle/123456789/8826
dc.identifier.volume1972
dc.languageEnglish
dc.language.isoen_USen_US
dc.publisherAmerican Institute of Physics Inc.en_US
dc.relation.ispartofOpen Accessen_US
dc.relation.ispartofAIP Conference Proceedings
dc.sourceScopus
dc.titleModelling brain activations and connectivity of pain modulated by having a loved one nearbyen_US
dc.title.alternativeAIP Conf. Proc.en_US
dc.typeConference Paperen_US
dspace.entity.typePublication

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