Publication: Effect Of Malaysian Thermal Spring Water As Adjunct Therapy For Mild To Moderate Acne Vulgarisms - A Prospective Randomised, Controlled Split Face Study
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Date
2024
Journal Title
Journal ISSN
Volume Title
Publisher
The Medical Journal of Malaysia
Abstract
Introduction: Acne is a common skin disease with a high psychosocial burden, affecting mostly adolescents and youth worldwide. Management of acne is often challenged by cutaneous side effects that leads to therapeutic intolerance, poor compliance and impaired efficacy.
Materials and Methods: This was a single-centre, evaluatorblinded, split-face, randomised study investigating the effects of thermal spring water (TSW) in improving efficacy and tolerability of standard acne therapy. Total of 31 participants with mild-to-moderate acne were recruited and subjected to TSW spray one side of the face 4 times daily for 6 weeks in addition to standard therapy. The other side received standard therapy only.
Results: Six (19.4%) males and 25 (80.6%) female with mean age 25.1±6.13 participated, 15 (48.4%) had mild acne while 16 (51.6%) had moderate acne. Seven (22.6%) were on oral antibiotics, 25 (80.6%) used adapalene, 6 (19.4%) tretinoin and 21 (67.7%) benzoyl peroxide. Skin hydration improved and better on spring water treated side with mean difference12.41±30.31, p = 0.04 at the forehead, 39.52±65.14, p < 0.01 at the cheek and 42.172±71.71, p < 0.01 at the jaw at week 6. Participants also report significant reduction in dryness at the treated side at week 6, mean difference 0.93±0.10, p < 0.001. TEWL, sebum and pH were comparable on both sides with no significant differences. Tolerability towards standard therapy improved as early week 2 with reduction of stinging following application of topical therapy (mean difference 0.62±1.43, p = 0.03), increase in skin feeling good (-1.79±1.70, p < 0.001) and skin suppleness (0.62±1.43, p < 0.001). These improvements were significantly maintained till week 6. Cardiff acne disability index significantly improved at week 6 (p<0.001) despite no significant changes in Comprehensive Acne Severity Scale score before and after treatment.
Description
PubMed,Volume 79 Issue 2 Page (157–164)
Keywords
Acne, thermal spring water, trans-epidermal water loss, hydration
Citation
Ummu Aiman Faisal, Adawiyah Jamil, Hafiz Jaafar , Wan Syaidatul Aqma & Mohan Arumugam (2024). Effects of Malaysian thermal spring water as adjunct therapy for mild to moderate acne vulgaris - a prospective, randomised, controlled, split face study. PubMed, 79(2), 157–164.