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Population data for 12 X-STRs loci in Malaysian Malay and Chinese populations

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Population data for 12 X-STRs loci in Malaysian Malay and Chinese populations.pdf (1.11 MB)

Date

2024

Authors

Aedrianee Reeza Alwi
Naji Arafat Mahat
Faezah Mohd Salleh
Seri Mirianti Ishar
Mohammad Rahim Kamaluddin
Mohd Radzniwan A. Rashid
Sharifah Nany Rahayu Karmilla Syed Hassan
Sasitaran Iyavoo

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Elsevier Ltd

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Abstract

The utilization of X-chromosome short tandem repeats (X-STRs) for human identification particularly in resolving complex kinship cases has been advocated. Since, forensic statistical parameters vary among different populations, and because the X-STRs population data representing the diverse population of Peninsular Malaysia remain unavailable, the specific attempt reported here for the Malays (n = 224) and Chinese (n = 201) populations appears forensically relevant to support the evidential value of the 12 X-STRs markers for human identification in Malaysia. Results derived from the Qiagen Investigator® Argus X-12 kit revealed that DXS10135 as the most polymorphic locus with high genetic diversity, polymorphic information content, heterozygosity as well as power of exclusion. Based on allele frequencies, the combined power of discrimination as well as the mean exclusion chance (MECKrüger, MECKishida, MECDesmarais and MECDesmaraisDuo) values for the Malays and Chinese were individually ≥0.999995532964908. As for the combined power of discrimination as well as the mean exclusion chance (MECKrüger, MECKishida, MECDesmarais and MECDesmaraisDuo) calculated based on haplotype frequencies, the values were ≥0.9999986410567 for the Malays and Chinese populations. In addition, results from the genetic distance, neighbor-joining phylogenetic tree and principal component analysis revealed close biogeographical distributions of the studied populations with other South East Asian populations. Hence, the utilization of the X-STRs data for identifying individuals among the Malays and Chinese populations in Peninsular Malaysia for forensic application appears as highly supported.

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Heliyon Volume 10, Issue 19 (page:1-8)

Keywords

X-STRs Forensic statistical parameters Malay Chinese Malaysia

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https://www.cell.com/heliyon/fulltext/S2405-8440(24)14085-6
 https://oarep.usim.edu.my/handle/123456789/23229
 https://www.scopus.com/record/display.uri?eid=2-s2.0-85204762971&origin=resultslist&sort=plf-f&src=s&sid=4631e6e4547e65656dc2185a027f2cb8&sot=b&sdt=b&s=TITLE-ABS-KEY%28Population+data+for+12+X-STRs+loci+in+Malaysian+Malay+and+Chinese+populations%29&sl=92&sessionSearchId=4631e6e4547e65656dc2185a027f2cb8&relpos=0

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