Krishnamoorthy MadhusudhanNor Eyzawiah binti HassanNorasnieda Binti Md ShukriShahrul Bin HitamIkmal Hisyam Bin Bakrin2024-05-272024-05-2720182393-335610.2478/rjr-2018-0021https://www.sciendo.com/article/10.2478/rjr-2018-0021https://oarep.usim.edu.my/handle/123456789/3922Volume 8 No. 31Small cell neuroendocrine carcinoma (SCNEC) of the nasopharynx and nasal cavity is a rare condition. It is an aggressive malignancy with a high recurrence rate. Despite its rarity in the sinonasal region, it may occur as a second primary malignancy. Patients with cancer of the head and neck region are more prone to develop a second primary tumor due to the field cancerization phenomenon, and a higher incidence is seen in those who have previously received radiation therapy. A detailed clinical and histopathological examination is pivotal to diagnose SCNEC as a second primary malignancy. We wish to highlight such a peculiar case from our center.en-USneuroendocrine carcinoma, nasopharyngeal carcinoma, second primary malignancy, small cell carcinomaArticle187192831