Syamsul K.M.W.Radzi S.M.Fadhil F.H.M.Noor H.M.Rehan M.M.2024-05-282024-05-2820171936661210.1166/asl.2017.88812-s2.0-85023751039https://www.scopus.com/inward/record.uri?eid=2-s2.0-85023751039&doi=10.1166%2fasl.2017.8881&partnerID=40&md5=5ed403e4986ebed4a330a99c71397b01https://oarep.usim.edu.my/handle/123456789/8535Kojic acid is a well known as natural whitening agent and widely use in skincare product formulation. However, kojic acid are water-soluble, unstable at high temperature for long term storage and cannot be directly incorporated in oil based skincare products. Therefore, natural-based kojic acid ester was produced to improve the properties via esterification reaction in the presence of immobilized lipase. The synthesized kojic acid ester was purified through crystallization method. Besides, bioassay study of the kojic acid ester and kojic acid performances on tyrosinase activity and free radical scavenging activity were also carried out. The result shows that, kojic acid gave the highest percentage of tyrosinase activity (77.16%) at 25% of ester concentration. While for kojic acid ester, it gave the highest percentage of tyrosinase activity (23.71%) at 50% of ester concentration. Whilst, the study on radical scavenging activity shows that kojic acid also yield higher percentage of radical scavenging activity which was 84.24% than kojic acid ester which gave 67.65% only. � 2017 American Scientific Publishers All rights reserved.en-USImmobilized lipaseKojic acidKojic acid estersTyrosinase activity and radical scavenging activityArticle47424744235