Noor Anisah Abu YazitNorsham Juliana NordinKamilah Muhammad HafidzNur Adilah Shuhada Abd AzizSofwatul Mokhtarah MaluinSahar AzmaniNur Islami Mohd Fahmi TengSrijit DasSuhaini Kadiman2024-11-262024-11-2620242024-11-26Noor Anisah Abu Yazit, Norsham Juliana, Kamilah Muhammad Hafidz, Nur Adilah Shuhada Abd Aziz, Sofwatul Mokhtarah Maluin, Sahar Azmani, Nur Islami Mohd Fahmi Teng, Srijit Das, & Suhaini Kadiman. (2024). Exploring Cognitive Changes in High-Risk Cardiac Patients Receiving Dexmedetomidine and Evaluating the Correlation between Different Cognitive Tools: A Cohort Study. Reviews in Cardiovascular Medicine, 25(8), 273–273. https://doi.org/10.31083/j.rcm25082731530-655010.31083/j.rcm2508273https://www.imrpress.com/journal/RCM/25/8/10.31083/j.rcm2508273https://oarep.usim.edu.my/handle/123456789/25222https://www.scopus.com/record/display.uri?eid=2-s2.0-85201577268&origin=resultslist&sort=plf-f&src=s&sid=02376eba7db8a847fde0c5ddb22647d7&sot=b&sdt=b&s=TITLE-ABS-KEY%28Exploring+Cognitive+Changes+in+High-Risk+Cardiac+Patients+Receiving+Dexmedetomidine+and+Evaluating+the+Correlation+between+Different+Cognitive+Tools%29&sl=97&sessionSearchId=02376eba7db8a847fde0c5ddb22647d7&relpos=0Indexed by WOS/ ScopusBackground: Mini-mental State Examination (MMSE) is widely accepted clinically for postoperative cognitive dysfunction (POCD) assessment. This study aims to investigate the post-operative cognitive changes among high-risk cardiothoracic patients and establish a standardised approach to post-surgery cognitive assessment. Methods: This is a prospective cohort study, where cognitive assessments were done 1-day before surgery, at discharge, and during 6 weeks of follow-up. Sample size calculation, accounting for an estimated 20% dropout rate, determined a minimum of 170 subjects were required for the study. Reduction of MMSE score of more than 2.5 was considered as having POCD. Score differences between groups were analysed using T-test and analysis of variance (ANOVA), while consistency between tools was analysed using correlation and regression. Results: A total of 188 patients completed the study, with a POCD prevalence of 20.2% and 6.9% at discharge and at the 6 week follow up, respectively. All cognitive tools show a significant difference between preoperative and postoperative scores. All tests show a significant moderate correlation with MMSE. Conclusions: In conclusion, it is imperative to employ a battery of cognitive assessments to evaluate cognitive changes comprehensively.en-USExploring Cognitive Changes in High-Risk Cardiac Patients Receiving Dexmedetomidine and Evaluating the Correlation between Different Cognitive ToolsWOS/Scopus16258