Mohd Yusri, M. A. Y.M. A. Y.Mohd YusriAbu Hassan, M. H.M. H.Abu HassanAzhari, S.S.Azhari2024-05-302024-05-302020Mohd Yusri, M. A. Y., Abu Hassan, M. H., & Azhari, S. (2020). Assessment of Disulfide-linked Gold Nanoparticles as Colorimetric Sensor for Human Chorionic Gonadotropin Detection. Malaysian Journal of Science Health & Technology, 5(1). https://doi.org/10.33102/mjosht.v5i1.1282601-000310.33102/mjosht.v5i1.128https://mjosht.usim.edu.my/index.php/mjosht/article/view/128https://oarep.usim.edu.my/handle/123456789/15528Gold nanoparticles (AuNPs) are a highly versatile compound to be used in sensing components due to their unique physicochemical and optical properties. Due to its flexibility for surface conjugation, glutathione disulfide-linked gold nanoparticle (AuNP-GSSG) was produced in this study to assess its sensing performance as a colorimetric sensor for human chorionic gonadotropin (HCG). Spectroscopic characterization of AuNP-GSSG confirmed the conjugation of GSSG onto the surfaceofAuNPs.AuNP-GSSGalsoshowedhighsensoryperformancewithgoodlinearityandlowdetectionlimit.However,due to the high percentage of interference, usage of AuNP-GSSG as an HCG sensor requires further pre-treatment step to reduce the interference and increase the sensor accuracy.en-USGold nanoparticles, Human chorionic gonadotropin, sensorArticle135Vol.5Issue 1(2020)