Nur Ezzaty Mohammad KazminHui Jan TanHana Maizuliana SolehanFatimah ZanirahWei Ming TanM Firdaus A BakarSarah Zulaikha Samad2024-05-302024-05-3020222022-9-27Mohammad Kazmin, N. E., Tan, H. J., Solehan, H. M., Fatimah Zanirah, Tan, W. M., A Bakar, M. F., & Samad, S. Z. (2022). Multiple Sclerosis – Challenges in Diagnosis. Malaysian Journal of Science Health & Technology, 8, 4–7. https://doi.org/10.33102/20222712601-000310.33102/2022271https://mjosht.usim.edu.my/index.php/mjosht/article/view/271https://oarep.usim.edu.my/handle/123456789/15544Volume: 8 (page: 4–7)Multiple Sclerosis is an inflammatory demyelinating disease that affects the central nervous system, and is uncommon among the Asian population. It can present with a variety of symptoms, depending on the location of the demyelinating plaques, which could also potentially mimic a range of neurological and non-neurological disorders. We report a 24-year-old woman who presented with recurrent non-specific lower limb numbness, without any other neurological symptoms or signs. The symptoms were presumed to be nonspecific, but they re-occurred eight months later, leading to a more extensive investigation, including whole spine and brain MRI. The MRI showed multiple white matter lesions that are hyperintense on T2W/FLAIR, seen at the right corona radiata, bilateral parietal lobes, right periventricular region and spinal cord, with a simultaneous presence of gadolinium-enhancing and nonenhancing lesions, fulfilling 2017 Mc Donald’s diagnostic criteria for multiple sclerosis. After the careful exclusion of differential diagnoses, she was given pulsed IV methylprednisolone for 5 days, followed by oral teriflunomide. She improved partially, and at 2 months following discharge, she was tolerating the medication well with no further relapses.en-USmultiple sclerosis; numbness; challenge; diagnosis; non-specificArticle478SPECIAL