Bahron, HHBahronKhaidir, SSSSKhaidirTajuddin, AMAMTajuddinRamasamy, KKRamasamyYamin, BMBMYamin2024-05-292024-05-2920190277-538710.1016/j.poly.2018.12.055WOS:000460495900009https://www.scopus.com/inward/record.uri?eid=2-s2.0-85060229906&doi=10.1016%2fj.poly.2018.12.055&partnerID=40&md5=f934a8202617f7f192acf1406ab36817https://oarep.usim.edu.my/handle/123456789/11175Polyhedron Volume 161, 15 March 2019, Pages 84-92A Schiff base ligand, 6,6'-dimethoxy-2,2'-[o-phenylenebis(nitrilomethylidyne)]diphenolato (LA), and its mononuclear and dinuclear Ni(II) and Co(II) complexes were synthesized. Structural elucidation was carried out via elemental analysis, molar conductivity, IR, NMR, UV-Vis spectroscopy, TGA and magnetic susceptibility. Single crystal X-ray diffraction of the Ni(LA) complex revealed a square planar geometry of the Ni(II) centre, with the ligand acting as a tetradentate ONNO chelate. Upon coordination to the metal centers, the nu(C=N) and nu(C-O) peaks shifted to lower frequencies, with appearance of new peaks assignable to nu(M-N) and nu(M-O) in the ranges 535-560 and 421-460 cm(-1), respectively. Ni(LA) and Ni-2(LA) complexes are diamagnetic, whereas the Co(LA) and Co-2(LA) complexes are paramagnetic with 3 unpaired electrons each. All the complexes displayed low molar conductivities in acetonitrile indicating non-electrolytic behavior. Anticancer screening against human colorectal cancer HCT116 cell lines revealed that both dinuclear complexes were more active than their mononuclear counterparts. Ni-2(LA) showed the highest potency with an IC50 value of 0.81 mu M. (C) 2019 Elsevier Ltd. All rights reserved.en-USMononuclearDinuclearComplexesSchiff baseAnticancerArticle8492161