Durratul Aqwa Mohd FaridNur A’fifah Husna ZahariZulfahmi SaidMohd Ifwat Mohd GhazaliLee Hao-ErnSyazwani Mohamad ZolSami AldhuwayhiMuhammad Syafiq Alauddin2024-05-292024-05-2920222022-10-12Mohd Farid, D.A.; Zahari, N.A.H.; Said, Z.; Ghazali, M.I.M.; Hao-Ern, L.; Mohamad Zol, S.; Aldhuwayhi, S.; Alauddin, M.S. Modification of Polymer Based Dentures on Biological Properties: Current Update, Status, and Findings. Int. J. Mol. Sci. 2022, 23, 10426. https://doi.org/10.3390/ ijms2318104261422-0067https://doi.org/10.3390/ijms231810426https://www.mdpi.com/1422-0067/23/18/10426https://oarep.usim.edu.my/handle/123456789/10517Volume 23 Issue 18 (page:Polymers remain an integral part of denture fabrication materials, specifically polymethylmetacrylate (PMMA). PMMA has been extensively used, particularly in construction as a denture base material. Nonetheless, various challenges, including microbial threats in the form of candidiasis occurrence, still remain a biological challenge to denture wearers. The present article comprehensively reviews the biomodifications introduced to denture components, in particular denture base material, to improve the overall biological properties, together with physical, mechanical, structural integrity, and optical properties. In addition, fundamental information specifically to PMMA as a conventional denture base material and the causative aetiological microbial agents for biological threat to dentures are exploreden-USpolymers; PMMA; denture; denture base; prosthodonticsArticle1182318