Nurul Jannah Abd RahmanSalina Mat RadziHanina Mohd NoorNorlelawati Ariffin2024-05-272024-05-2720152278-4357https://www.wjpps.com/Wjpps_controller/abstract_id/2551https://oarep.usim.edu.my/handle/123456789/4065Volume 4, Issue 1Antimicrobial study of synthesized ferulate esters was successfully carried out against both Gram-positive (Bacillus subtilis, Staphylococcus epidermidis and Staphylococcus aureus) and Gram-negative (Salmonella typhimurium, Klabsiella Pneumoniae and Escherichia coli) bacteria. Screening by agar diffusion test was employed for preliminary features followed by Minimum inhibitory concentration (MIC) and Minimum bactericidal concentration (MBC) assays. Ferulate esters demonstrated anti-bacterial activity with diameter of inhibition zones ranged from 8 to 16 mm for S. typhimurium, E. coli, S. epidermidis and S. aureus. For MIC assay, the minimum concentration of ferulate esters against E. coli was 50% followed by S. typhimurium (33.3%), S. epidermidis (20%) and S. aureus (20%). While for MBC assay, ferulate esters only showed bacteriostatic effect. Therefore, this research proved that the ferulate esters possess moderate antibacterial inhibition against both types of bacteria.en-USFerulate esters, agar well diffusion, MIC, MBCArticle1143115141