Muna E. RaypahAsma Nadia FarisMawaddah Mohd AzlanNik Yusnoraini YusofFariza Hanim SuhailinRafidah Hanim ShuebIrneza IsmailFatin Hamimi Mustafa2024-05-292024-05-2920222022-12-22Raypah, M.E.; Faris, A.N.; Mohd Azlan, M.; Yusof, N.Y.; Suhailin, F.H.; Shueb, R.H.; Ismail, I.; Mustafa, F.H. Near-Infrared Spectroscopy as a Potential COVID-19 Early Detection Method: A Review and Future Perspective. Sensors 2022, 22, 4391. https:// doi.org/10.3390/s221243911424-822010.3390/s22124391https://www.mdpi.com/1424-8220/22/12/4391https://www.scopus.com/record/display.uri?eid=2-s2.0-85131522798&origin=resultslist&sort=plf-f&src=s&sid=afbb30fec47e68324a407a39afdba60b&sot=b&sdt=b&s=TITLE-ABS-KEY%28%22%09Near-infrared+Spectroscopy+as+a+Potential+Covid-19+Early+Detection+Method%3A+A+Review+and+Future+Perspective%22%29&sl=124&sessionSearchId=afbb30fec47e68324a407a39afdba60bhttps://oarep.usim.edu.my/handle/123456789/10541Volume 22 Issue 12The coronavirus disease 2019 (COVID-19) pandemic is a worldwide health anxiety. The rapid dispersion of the infection globally results in unparalleled economic, social, and health impacts. The pathogen that causes COVID-19 is known as a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). A fast and low-cost diagnosis method for COVID-19 disease can play an important role in controlling its proliferation. Near-infrared spectroscopy (NIRS) is a quick, non-destructive, non-invasive, and inexpensive technique for profiling the chemical and physical structures of a wide range of samples. Furthermore, the NIRS has the advantage of incorporating the internet of things (IoT) application for the effective control and treatment of the disease. In recent years, a significant advancement in instrumentation and spectral analysis methods has resulted in a remarkable impact on the NIRS applications, especially in the medical discipline. To date, NIRS has been applied as a technique for detecting various viruses including zika (ZIKV), chikungunya (CHIKV), influenza, hepatitis C, dengue (DENV), and human immunodeficiency (HIV). This review aims to outline some historical and contemporary applications of NIRS in virology and its merit as a novel diagnostic technique for SARS-CoV-2.en-USnear-infrared spectroscopy; SARS-CoV-2; COVID-19; viruses; chemometrics; diagnosticsArticle1172212