Mohammed Nasser AlhajjEsam HalboubNorlela YacobSadeq Ali Al‑MaweriSiti Fauzza AhmadAsja CelebićHesham M. Al‑MekhlafiNosizana Mohd Salleh2024-07-132024-07-1320242024-7-10Mohammed Nasser Alhajj , Esam Halboub, Norlela Yacob , Sadeq Ali Al‑Maweri , Siti Fauzza Ahmad , Asja Celebić , Hesham M. Al‑Mekhlaf and Nosizana Mohd Salleh Adhesion of Candida Albicans to digital versus conventional acrylic resins: a systematic review and meta-analysis. (2024). Adhesion of Candida Albicans to digital versus conventional acrylic resins: a systematic review and meta-analysis. (2024). BMC Oral Health, 24, 1–16.1472-6831956-1710.1186/s12903-024-04083-https://oarep.usim.edu.my/handle/123456789/20712https://bmcoralhealth.biomedcentral.com/articles/10.1186/s12903-024-04083-2BMC Oral Health, Volume 24, Page (1–16)Background The present systematic review and meta-analysis investigated the available evidence about the adher‑ ence of Candida Albicans to the digitally-fabricated acrylic resins (both milled and 3D-printed) compared to the con‑ ventional heat-polymerized acrylic resins. Methods This study followed the guidelines of the Preferred Reporting Items for Systematic Review and Metaanalyses (PRISMA). A comprehensive search of online databases/search tools (Web of Science, Scopus, PubMed, Ovid, and Google Scholar) was conducted for all relevant studies published up until May 29, 2023. Only in-vitro studies comparing the adherence of Candida albicans to the digital and conventional acrylic resins were included. The quanti‑ tative analyses were performed using RevMan v5.3 software. Results Fourteen studies were included, 11 of which were meta-analyzed based on Colony Forming Unit (CFU) and Optical Density (OD) outcome measures. The pooled data revealed signifcantly lower candida coloniza‑ tion on the milled digitally-fabricated compared to the heat-polymerized conventionally-fabricated acrylic resin materials (MD=−0.36; 95%CI=−0.69, −0.03; P=0.03 and MD=−0.04; 95%CI=−0.06, −0.01; P=0.0008; as meas‑ ured by CFU and OD respectively). However, no diferences were found in the adhesion of Candida albicans between the 3D-printed digitally-fabricated compared to the heat-polymerized conventionally-fabricated acrylic resin materials (CFU: P=0.11, and OD: P=0.20). Conclusion The available evidence suggests that candida is less likely to adhere to the milled digitally-fabricated acrylic resins compared to the conventional onesen-USCandida AlbicansDigital dentureCAD-CAMAcrylic resinProsthodonticstext::journal::journal article303303241