Dinah Farhanah JamalQuratul Ain RozaimeeNadila Haryani OsmanAtikah Mohd SukorMarjanu Hikmah EliasNor Aripin ShamaanSrijit DasNazefah Abdul Hamid2024-05-282024-05-2820222022-10-25Jamal, D.F.; Rozaimee, Q.A.; Osman, N.H.; Mohd Sukor, A.; Elias, M.H.; Shamaan, N.A.; Das, S.; Abdul Hamid, N. Human Papillomavirus 16 E2 as an Apoptosis-Inducing Protein for Cancer Treatment: A Systematic Review. Int. J. Mol. Sci. 2022, 23, 12554. https://doi.org/10.3390/ijms2320125541422-0067444-2410.3390/ijms232012554https://www.mdpi.com/1422-0067/23/20/12554https://oarep.usim.edu.my/handle/123456789/5785Int. J. Mol. Sci. 2022, 23(20),Human papillomavirus type 16 (HPV-16) is a well-known etiological factor for cervical and oropharyngeal cancers. The E2 protein, the product of an early-transcribed gene in HPV–16, is postulated to cause the death of cancerous cells via p53-dependent and p53-independent pathways. The main aim of the present systematic review was to study the HPV 16-E2 protein as an apoptosis-inducer agent. A thorough search of MEDLINE/PubMed, Science Direct, Scopus, and EBSCOhost databases was conducted for relevant studies on HPV AND apoptosis OR cell death where HPV 16-E2 was involved. The search identified 967 publications. Eleven records dated from 1 January 1997 to 16 February 2022 were found to meet the inclusion criteria and were eligible for data extraction and inclusion. All studies concluded that HPV 16-E2 was able to induce cell death in transfected cells. E2 proteins from the high-risk HPV–16 were able to induce apoptosis through different apoptotic pathways depending on the location of the expressed gene. However, the mechanism was still unclear, and further studies are warranted.enapoptosis; cell death; E2 protein; human papillomavirus; HPV 16Article1172320