Siti Asmat Md ArepenDinie Qistina RajalieAzreen Zaira Abu BakarNor Azirah SalahuddinNour Hanan Daniah Mohd BakhitAhmad Anwaar Muhammad SaifullahNor Eyzawiah Hassan2024-06-162024-06-1620232024-1-9Siti Asmat Md Arepen, Dinie Qistina Rajalie, Abu, Z., Nor Azirah Salahuddin, Nour, Anwaar, A., & Nor Eyzawiah Hassan. (2023). A Case Report of Oral Ulcer in Rheumatoid Arthritis: A Diagnostic and Management Dilemma. Malaysian Journal of Medicine and Health Sciences/Malaysian Journal of Medicine and Health Sciences, 19(s19), 31–33. https://doi.org/10.47836/mjmhs.19.s19.92636-93462327-1110.47836/mjmhs.19.s19.9https://oarep.usim.edu.my/handle/123456789/20071Malaysian Journal of Medicine and Health Sciences Volume 19 Issue (SUPP19) Page (31-33)Chronic oral ulcer in patients with rheumatoid arthritis is a diagnostic challenge in primary health care. The possible causes include the disease itself, side effect of treatment, malignancy and infections. This is a case of a 63-year-old woman with underlying rheumatoid arthritis presented with chronic solitary oral ulcer. She was on oral methotrexate (MTX) and high dose folic acid for five years with good compliance. Tissue biopsy showed marked inflammatory cells infiltration and nuclear hyperchromatism with no evidence of malignancy nor infection. The ulcer was resolved after completing antifungal treatment for six weeks following failure of improvement after empirical antibiotic, elimination of possible trauma and discontinuation of MTX. The fungal staining was negative. There are possibilities of false negative results, thus broadened diagnosis with repeated and further investigations are recommended in cases who did not respond to conventional treatment.en-USOral ulcerrheumatoid arthritismethotrexateautoimmune diseaseimmunocompromised patienttext::journal::journal article313319SUPP19