Salleh H.M.Chong S.-L.Othman R.Hazni H.Ahmad K.Mohd Yusof M.Y.Z.Fauzi N.W.Wahab H.A.Liew S.Y.Awang K.2024-05-292024-05-29201912757202-s2.0-85071253546https://www.scopus.com/inward/record.uri?eid=2-s2.0-85071253546&partnerID=40&md5=b1066057a4b5b46dbac2873cafcf1979https://msptm.org/vol-36-no-2-june/https://msptm.org/files/Vol36No2/357-366-Awang-K.pdfhttps://oarep.usim.edu.my/handle/123456789/9859WOS:000475610700005Tropical Biomedicine 36(2): 357–366 (2019)Dengue fever is one of major health problem around the world including Malaysia. It is caused by the arthropode-borne flavivirus and transmitted by the bite of the Aedes aegypti or Aedes albopictus mosquito infected with one of the four dengue virus serotypes (DENV-1, DENV-2, DENV-3, or DENV-4). In this study, a screening exercise of various Malaysian medicinal plants showed that the extracts of Lawsonia inermis, Dryobalanops aromatica, Punica granatum, Zizyphus jujuba Lam. and Zingiber zerumbet exhibited potent inhibitory activity against NS2B-NS3 serine protease. The methanol extracts of Dryobalanops aromatica showed inhibition of 99.70 % at concentration of 200 �g/mL with IC50 value of 0.30 � 0.16 �g/mL. � 2019, Malaysian Society for Parasitology. All rights reserved.en-USArticle357366362