Wan Nor Fazila Hafizan Wan NikHani Ajrina ZulkefleeSiti Nadirah Ab RahimTuan Salwani Tuan Ismail2024-05-282024-05-2820232023-1-31Wan Nik WNFH, Zulkeflee HA, Ab Rahim SN, Tuan Ismail TS. Association of vitamin D and magnesium with insulin sensitivity and their influence on glycemic control. World J Diabetes 2023; 14(1): 26-34 Wan Nik WNFH, Zulkeflee HA, Ab Rahim SN, Tuan Ismail TS. Association of vitamin D and magnesium with insulin sensitivity and their influence on glycemic control. World J Diabetes 2023; 14(1): 26-34 [PMID: 36684386 DOI: 10.4239/wjd.v14.i1.26]1948-935810.4239/wjd.v14.i1.26https://www.wjgnet.com/1948-9358/full/v14/i1/26.htmhttps://oarep.usim.edu.my/handle/123456789/7337Volume: 14 Issue :1 (page: 26-34)Insulin resistance increases the risk of developing diabetes, and the degree of resistance influences the glycemic control of patients with diabetes. Numerous researchers have focused on improving insulin sensitivity in order to prevent diabetes-related complications and other chronic diseases. Several studies have also linked vitamin D levels to insulin secretion and resistance, given that both vitamin D and its receptor complex play important roles in regulating pancreatic β-cells. It has been suggested that vitamin D supplementation improves vitamin D levels, but further research is needed to confirm this as neither insulin function nor glycemic control improves when vitamin D levels increase. Magnesium is a cofactor for many enzymes. Although the role of magnesium in the management of diabetes has long been evaluated, it has not yet been determined whether magnesium supplements improve insulin function. However, several researchers have found that patients with good glycemic control have high magnesium levels. Magnesium is closely related to vitamin D and is necessary for the transport and activation of vitamin D in humans. Combined supplementation with vitamin D and magnesium improves glycemic control in patients with diabetes.en-USVitamin D; Magnesium; Diabetes; Insulin sensitivity; Insulin resistance; Glycemic controlArticle2634141