Sofwatul Mokhtarah MaluinFarah Hanan Fathihah JaffarKhairul OsmanAini Farzana ZulkefliMohd Farisyam Mat RosSiti Fatimah Ibrahim2024-09-252024-09-2520242024-9-25Sofwatul Mokhtarah Maluin, Farah Hanan, Khairul Osman, Aini Farzana Zulkefli, Mohd Farisyam Mat Ros, & Siti Fatimah Ibrahim. (2024). Exploring edible bird nest’s potential in mitigating Wi‐Fi’s impact on male reproductive health. Reproductive Medicine and Biology, 23(1). https://doi.org/10.1002/rmb2.126061445-578110.1002/rmb2.12606https://onlinelibrary.wiley.com/doi/epdf/10.1002/rmb2.12606https://oarep.usim.edu.my/handle/123456789/22922Reproductive Medicine and Biology Volume 23, Issue 1 (page:1-13)Purpose: This study aimed to evaluate the protective effects of edible bird nest (EBN)against the detrimental impact of Wi-Fi on male reproductive health. Specifically, itexamines whether EBN can mitigate Wi-Fi-induced changes in male reproductive hor-mones, estrogen receptors (ER), spermatogenesis, and sperm parameters.Methods: Thirty-six adult male rats were divided into six groups (n = 6): Control,Control EBN, Control E2, Wi-Fi, Wi-Fi+EBN, and Wi-Fi+E2. Control EBN and Wi-Fi+EBN groups received 250 mg/kg/day EBN, while Control E2 and Wi-Fi+E2 groupsreceived 12 μg/kg/day E2 for 10 days. Wi-Fi exposure and EBN supplementationlasted eight weeks. Assessments included organ weight, hormone levels (FSH, LH,testosterone, and E2), ERα/ERβ mRNA and protein expression, spermatogenic mark-ers (c-KIT and SCF), and sperm quality.Results: Wi-Fi exposure led to decreased FSH, testosterone, ERα mRNA, and spermquality (concentration, motility, and viability). EBN supplementation restored serumFSH and testosterone levels, increased serum LH levels, and the testosterone/E2ratio, and normalized mRNA ERα expression. Additionally, EBN increased sperm con-centration in Wi-Fi-exposed rats without affecting motility or viability.Conclusions: EBN plays a crucial role in regulating male reproductive hormones andspermatogenesis, leading to improved sperm concentration. This could notably ben-efit men experiencing oligospermia due to excessive Wi-Fi exposureen-USedible bird nestinfertilityradiofrequency radiationspermWi-FiExploring Edible Bird Nest's Potential In Mitigating Wi-fi's Impact On Male Reproductive Healthtext::journal::journal article::research article113123