Nurlaily, AANurlailyNoraini, SSNorainiSaid, SNSNSaidJayachandran, RRJayachandranAzlina, MMAzlinaOthman, AAOthmanShamaan, NANAShamaanNoh, NANANoh2024-05-292024-05-292016Nurlaily, A., Noraini, S., Said, S. N., Jayachandran, R., Azlina, M., Othman, A., Shamaan, N. A., & Noh, N. A. (2016). Phoenix dactylifera (date fruits) administration to animal models of neurological diseases: A systematic review of health benefits. Current Topics in Nutraceutical Research, 14(3), 181+. https://link.gale.com/apps/doc/A479943048/HRCA?u=anon~f7a77720&sid=googleScholar&xid=0c09994d1540-7535WOS:000384942900001https://go.gale.com/ps/i.do?id=GALE%7CA479943048&sid=googleScholar&v=2.1&it=r&linkaccess=abs&issn=15407535&p=HRCA&sw=w&userGroupName=anon%7Ef7a77720https://web.s.ebscohost.com/ehost/detail/detail?vid=0&sid=cdbc3494-c0b4-4a70-8740-adff6c3953e8%40redis&bdata=JnNpdGU9ZWhvc3QtbGl2ZSZzY29wZT1zaXRl#db=a9h&AN=119800952https://oarep.usim.edu.my/handle/123456789/11095A systematic review of literature was conducted to examine the effects of date fruit (Phoenix dactylifera) interventions aimed at alleviating neurological diseases in animal models. Searches were conducted on electronic databases including EMBASE, PubMed, Scopus and Web of Science as well as hand searching. Retrieved studies represented a variety of intervention approaches (types of extraction, parts of plant used) with animal models of ischemic stroke, Alzheimer's disease, and substance -induced brain damage. Phoenix dactylifera interventions were associated with reduced degeneration of neurons, reduced oxidative stress markers, improved antioxidant status and neuronal histological changes in ischemic stroke.and brain damage when compared to the control. Phoenix dactylifera was also found to reduce oxidative stress level and improve endogenous antioxidant status, lower plasma level of beta-amyloid and neuroinflammatory cytokine, improved neurobehavioral deficits and cognitive performances in the Alzheimer's group. This review suggests that there is an association between Phoenix dactylifera and improvement of neurological disease markers in animal models of neurological diseases. The effects of Phoenix dactylifera by reducing oxidative stress level and improving antioxidant status in neurological diseases render it as a potential neuroprotective agent. However, further studies are needed to confirm the role of Phoenix dactylifera in conferring neuroprotective activity.en-USAntioxidant;Brain diseases;Date fruits;Neuroprotection;Oxidative stressArticle181189143