Noor Afi dah MSNoor Laili MMNik Malihan NSNur Syahrina RahimNorfadzilah MY2024-05-282024-05-282011MS, Noor & MM, Noor & NS, NikMalihan & Rahim, Nur & MY, NorFadzilah. (2011). Liver Allograft Biopsies: Experience in Hospital Selayang. The Malaysian journal of pathology. 33. 142.0126-8635http://www.mjpath.org.my/2015/v37n2/abstracts.pdfhttps://oarep.usim.edu.my/handle/123456789/7404PosterIntroduction: Liver biopsies are important to document any allograft rejection in liver transplantation. As one of the main centres providing liver transplant services, we are fortunate to experience dealing with liver allograft biopsies. Here, we briefl y describe our experience over a 7-year period. Materials and Methods: All reports of liver allograft biopsies performed from January 2004 to December 2010 in Hospital Selayang along with the relevant clinicopathological data were retrieved from the Department of Pathology archives using Cerner Pathnet Application. Results: There were 29 biopsies done from 18 patients aged between 19 months to 47 years old. Eleven of them were from males and 7 were female patients. There were 10 Malays, 5 were Chinese and 3 were Indians. Biliary atresia, Tyrosinaemia, Alagille’s syndrome and fulminant liver failure were some of the earlier indications or aetiologies for the liver transplantation. Most of them showed abnormal liver enzymes prior to allograft biopsy. The biopsies were evaluated using Banff scheme for liver allograft rejection. Ten (34.5%) of the cases showed acute rejection, 2 of the cases was indeterminate and another 2 cases showed chronic rejection. Fourteen (48.3%) of the cases showed no evidence of rejection. Drug induced injury, chronic biliary outfl ow obstruction, vanishing bile duct syndrome and chronic hepatitis were among the histopathological changes found in the allograft biopsies of these 14 cases. Conclusion: Liver biopsy is useful to evaluate graft dysfunction and to confi rm clinically suspected rejection. Adequate interpretation is dependent on adequacy of sampling, knowledge of differential diagnoses, clinical aspects of transplant hepatology and also close interaction with the clinical team.enliver allograft biopsyliver transplantrejectionArticle142142332