Hairin TahaA Hamid A HadiNoraziah NordinIbrahim A NajmuldeenKhalit MohamadOsamu ShirotaAlfarius E NugrohoWong Chin PiowToshio KanedaHiroshi Morita2024-05-282024-05-2820111347-522X10.1248/cpb.59.896https://www.jstage.jst.go.jp/article/cpb/59/7/59_7_896/_articlehttps://oarep.usim.edu.my/handle/123456789/6884Volume 59 Issue 7Pseuduvarines A (1) and B (2), two new dioxoaporphine alkaloids with an amino moiety, were isolated from the stem bark of Pseuduvaria rugosa and their structures were elucidated by combination of 2D-NMR spectroscopic analysis. Pseuduvarines A (1) and B (2) showed cytotoxicity against MCF7, HepG2, and HL-60 (1: IC50, 0.9, 21.7, and >50.0 μM, respectively, 2: IC50 >50.0, 15.7, and 12.4 μM, respectively).en-USpseuduvarine A; pseuduvarine B; dioxoaporphine; Pseuduvaria rugosa; cytotoxic activityArticle896897597