Muhammad Shazwan SuhimanMuhammad Aliff MohamadAsral Wirda Ahmad AsnawNur Syahrina RahimNazefah Abdul HamidMaiza MasriHayati Abdul RahmanNur Fariha Mohd Manzor2024-05-282024-05-282015Shazwan, Muhammad & Aliff, Muhammad & Asnawi, Asral & Rahim, Nur & Abdul Hamid, Nazefah & Masri, Maizatul & Rahman, Hayati & Mohd Manzor, Fariha. (2015). Regulation of microRNA in antiphospholipid syndrome.0126-8635https://oarep.usim.edu.my/handle/123456789/4382Conference: The 2015 Annual Scientific Meeting of the College of Pathologists, Academy of Medicine Malaysia & 40th Anniversary Celebration of the Pathology AdvocatesAt: Berjaya Time Square Hotel, Kuala LumpurIntroduction: Antiphospholipid antibodies are autoantibodies that attack phospholipid through anti-b2-Glycoprotein-1. The actions by these antibodies are associated with various sites of thrombosis and pregnancy mobidity which is also known as the antiphospholipid sysdrome (APS). The pathogenesis of APS is still not elucidated. Recently, microRNA expressions in many types of diseased tissues have been identified and linked to the involvement in both pathology and progression of diseases. Therefore, a systematic review was performed to search the literature for research papers focusing on microRNA expression profile in APS. Methodology: An electronic search was performed till March 2015. Three search engines; EBCOHOST, PROQUEST AND OVID were used to identify literature related to expression of specific microRNA in APS. Two reviewers independently scrutinized titles and abstracts before examining the eligible of studies that met the inclusion criteria. A total of 350 papers were found and screened. Results: Only one study fulfilled the inclusion criteria. The microRNAs found to be associated with APS regulation were miR-19b and miR-20a. No data was found on specific microRNA expressed in obstetric antiphospholipid syndrome. Discussion: Limited data on expressions of microRNA in APS suggests that further research in this field is required. Conclusion: Characterization of microRNA profile in blood and also in placenta tissue of patients with APS could be a useful model to explain the regulation of certain genes involved.enArticle203203372