Marjanu Hikmah Binti EliasNurunnajah LazimZulazmi Bin SutajiMohammad Azrai AbuAbdul Kadir Abdul KarimAzizah UgusmanSaiful Effendi SyafruddinMohd Helmy MokhtarMohd Faizal Ahmad2024-05-282024-05-2820232023-4-19Elias, M.H.; Lazim, N.; Sutaji, Z.; Abu, M.A.; Abdul Karim, A.K.; Ugusman, A.; Syafruddin, S.E.; Mokhtar, M.H.; Ahmad, M.F. HOXA10 DNA Methylation Level in the Endometrium Women with Endometriosis: A Systematic Review. Biology 2023, 12, 474. https:// doi.org/10.3390/biology12030472079-773710.3390/biology12030474https://www.mdpi.com/2079-7737/12/3/474https://oarep.usim.edu.my/handle/123456789/7402Volume 12 Issue 3 Page (1-11)Endometriosis is an inflammatory chronic systemic disease resulting in pelvic pain and infertility. However, despite a high prevalence of endometriosis, disease identification is still insufficient, and a high percentage of misdiagnosing was observed. Hence, a comprehensive study needs to be done to improve our understanding of the pathogenesis of endometriosis. Aberrant hypermethylation of HOXA10 has been reported to play a role in endometriosis. Thus, a comprehensive literature search was conducted to identify the DNA methylation level of HOXA10 among endometriosis patients across populations. The literature search was done using PubMed, Scopus, EBSCOhost, and Science Direct applying (HOXA10 OR “homeobox A10” OR “HOXA-10” OR HOX1) AND (“DNA methylation” OR methylation) AND (endometriosis OR endometrioma) as keywords. From 491 retrieved studies, five original articles investigating the DNA methylation level of HOXA10 from endometrium tissues among endometriosis women were included. All five included studies were classified as high-quality studies. High HOXA10 DNA methylation level was observed in the endometrium tissue of women with endometriosis in all the included studies. The secretory phase was identified as the best sampling time for HOXA10 DNA methylation study in endometriosis, and the most studied DNA methylation site is the promoter region of the HOXA10. However, more studies are needed to expose the HOXA10 mechanism in the pathogenesis of endometriosis.en-USDNA methylation; endometriosis; endometrium; eutopic endometrium; ectopic endometrium; secretory phase; proliferative phaseArticle11112474