Development Of Cellulose-based Films Containing Salicylic Acid For Wound Dressing Applications: Fabrication, Properties And In Vitro Assessment

Mohd Ibnu Haikal Ahmad SohaimyMuhammad Amir Amzar IsmailAzwani Sofia Ahmad KhiarNorizah Mhd SarbonNora Salina Md SalimHanis Nadia YahyaMohd Ikmar Nizam Mohamad Isa2024-09-052024-09-0520242024-8-31Mohd Ibnu Haikal Ahmad Sohaimy, Muhammad Amir Amzar Ismail, Azwani Sofia Ahmad Khiar, Norizah Mhd Sarbon, Nora Salina Md Salim, Hanis Nadia Yahya and Mohd Ikmar Nizam Mohamad Isa Development of cellulose-based films containing salicylic acid for wound dressing applications: Fabrication, properties and in vitro assessment. (2024). Journal of Bioactive and Compatible Polymers, 39(4), 1–13. https://doi.org/10.1177/088391152412535600883-9115761-3610.1177/08839115241253560https://oarep.usim.edu.my/handle/123456789/22501https://journals.sagepub.com/doi/10.1177/08839115241253560Journal of Bioactive and Compatible Polymers, Volume 39 Issue 4 Page (1–13)A wound dressing is important to ensure an efficient healing process while protecting the wound area. This research study combined 2-hydroxyethyl cellulose (2HEC)—an etherified cellulose derivative with salicylic acid (SA) to develop a single layer and investigate the 2HEC viability as wound dressing material. Nine different samples with different compositions of SA, from 5 wt.% to 40 wt.% (with an interval of 5 wt.%) and one control sample without adding SA were prepared via the solution casting method. The 2HEC-SA films were studied regarding the effects of SA composition on antimicrobial properties (Staphylococcus aureus) via the well-diffusion method. Additionally, degradability, mechanical properties, X-ray diffraction (XRD), and Fourier transform infrared (FTIR) of 2HEC-SA films have also been tested. The strongest antimicrobial effect of 2HEC-SA film was obtained at 40 wt.% with a 16 mm inhibition zone diameter. There was a noticeable decreasing weight loss pattern in the degradation test and the tensile strength of 2HEC-SA film when the composition of salicylic acid is increased. 2HEC-SA film changes phases from amorphous to crystalline starting at 25 wt.% of salicylic acid as seen through XRD, while FTIR shows that complexation of 2HEC and salicylic acid occurred at 1050 cm−1.en-USWound dressingbiocompatible2-hydroxyethyl cellulosesalicylic acidDevelopment Of Cellulose-based Films Containing Salicylic Acid For Wound Dressing Applications: Fabrication, Properties And In Vitro Assessmenttext::journal::journal article::research article11300