Nasir YusoffNorrul Aikma MohamedNor Azila Noh2024-05-292024-05-2920222022-4-27Yusoff, N. ., Mohamed, N. A. ., & Noh, N. A. . (2022). Cognitive process in high neuroticism: incompatible flexibility in frontal brain region. Bangladesh Journal of Medical Science, 21(1), 129–134. https://doi.org/10.3329/bjms.v21i1.563382223-472110.3329/bjms.v21i1.56338https://www.banglajol.info/index.php/BJMS/article/view/56338https://oarep.usim.edu.my/handle/123456789/10582Volume: 21 No: 1 (page:129-134)Objective: This study examines the difference of interference effect in high and low neuroticism. Material and Methods: Low and high groups of neuroticism performed the congruent and incongruent Stroop Colour Word task in the Event Related Potential session. The ERP P300 was extracted and analysed. Results: High neuroticism exhibited larger P300 amplitude than low neuroticism in both congruent and incongruent condition. Conclusion: High neuroticism appraises conflict and non-conflict condition under incompatibility manner driven by prefrontal cortical top–down control.en-USevoked potentials; interference effect; neuroticism; response inhibitionArticle129134211