Mohan D.Khairullah N.F.How Y.P.Sajab M.S.Kaco H.2024-05-292024-05-2920202073436010.3390/polym120409862-s2.0-85085249060https://www.scopus.com/inward/record.uri?eid=2-s2.0-85085249060&doi=10.3390%2fPOLYM12040986&partnerID=40&md5=896e3ffcc80749536d7553a24b7f6dd9https://www.mdpi.com/2073-4360/12/4/986https://oarep.usim.edu.my/handle/123456789/9832Polymers 2020, 12(4), 986; https://doi.org/10.3390/polym12040986Drug delivery constitutes the formulations, technologies, and systems for the transport of pharmaceutical compounds to specific areas in the body to exert safe therapeutic effects. The main criteria for selecting the correct medium for drug delivery are the quantity of the drug being carried and the amount of time required to release the drug. Hence, this research aimed to improve the aforementioned criteria by synthesizing a medium based on calcium carbonate-nanocellulose composite and evaluating its efficiency as a medium for drug delivery. Specifically, the efficiency was assessed in terms of the rates of uptake and release of 5-fluorouracil. Through the evaluation of the morphological and chemical properties of the synthesized composite, the established 3D printing profiles of nanocellulose and CaCO3 took place following the layer-by-layer films. The 3D printed double laminated CaCO3-nanocellulose managed to release the 5-fluorouracil as an effective single composition and in a time-controlled manner. � 2020 by the authors.en-US3D printersCalciteCalcium carbonateCelluloseCellulose nanocrystalsEfficiencyLaminatingNanocelluloseNanocomposite filmsTargeted drug delivery5-fluorouracilControlled releaseIts efficienciesLayer-by-layer filmsNanocellulose filmsPharmaceutical compoundsTherapeutic effectsTime-controlledControlled drug deliveryArticle124986