Browsing by Author "A Hamid A Hadi"

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    Publication
    Pseuduvarines A And B,two New Cytotoxic Dioxoaporphine Alkaloids From Pseuduvaria Rugosa
    (Pharmaceutical Society of Japan, 2011)
    Hairin Taha
    ;
    A Hamid A Hadi
    ;
    Noraziah Nordin
    ;
    Ibrahim A Najmuldeen
    ;
    Khalit Mohamad
    ;
    Osamu Shirota
    ;
    Alfarius E Nugroho
    ;
    Wong Chin Piow
    ;
    Toshio Kaneda
    ;
    Hiroshi Morita
    Pseuduvarines A (1) and B (2), two new dioxoaporphine alkaloids with an amino moiety, were isolated from the stem bark of Pseuduvaria rugosa and their structures were elucidated by combination of 2D-NMR spectroscopic analysis. Pseuduvarines A (1) and B (2) showed cytotoxicity against MCF7, HepG2, and HL-60 (1: IC50, 0.9, 21.7, and >50.0 μM, respectively, 2: IC50 >50.0, 15.7, and 12.4 μM, respectively).