Browsing by Author "Hiroshi Morita"

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    Chisomicines D and E, Two New Limonoids from Chisocheton ceramicus
    (The Japan Institute of Heterocyclic Chemistry, 2012)
    Ibrahim A. Najmuldeen
    ;
    A. Hamid A. Hadi
    ;
    Khalit Mohamad
    ;
    Khalijah Awang
    ;
    Kamal Aziz Ketuly
    ;
    Mat Ropi Mukhtar
    ;
    Hairin Taha
    ;
    Noraziah Nordin
    ;
    Marc Litaudon
    ;
    Françoise Guéritte
    ;
    Alfarius Eko Nugroho
    ;
    Hiroshi Morita
    Two new limonoids, chisomicines D and E (1 - 2) have been isolated from the bark of Malaysian Chisocheton ceramicus (Miq.) C. DC. Their structures were elucidated on the basis of 1D and 2D-NMR data analysis.
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    Publication
    Pseuduvarines A And B,two New Cytotoxic Dioxoaporphine Alkaloids From Pseuduvaria Rugosa
    (Pharmaceutical Society of Japan, 2011)
    Hairin Taha
    ;
    A Hamid A Hadi
    ;
    Noraziah Nordin
    ;
    Ibrahim A Najmuldeen
    ;
    Khalit Mohamad
    ;
    Osamu Shirota
    ;
    Alfarius E Nugroho
    ;
    Wong Chin Piow
    ;
    Toshio Kaneda
    ;
    Hiroshi Morita
    Pseuduvarines A (1) and B (2), two new dioxoaporphine alkaloids with an amino moiety, were isolated from the stem bark of Pseuduvaria rugosa and their structures were elucidated by combination of 2D-NMR spectroscopic analysis. Pseuduvarines A (1) and B (2) showed cytotoxicity against MCF7, HepG2, and HL-60 (1: IC50, 0.9, 21.7, and >50.0 μM, respectively, 2: IC50 >50.0, 15.7, and 12.4 μM, respectively).