Browsing by Author "Mohd Yusof M.Y.Z."

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    Publication
    Dengue protease inhibition activity of selected malaysian medicinal herbs
    (Malaysian Society for Parasitology, 2019)
    Salleh H.M.
    ;
    Chong S.-L.
    ;
    Othman R.
    ;
    Hazni H.
    ;
    Ahmad K.
    ;
    Mohd Yusof M.Y.Z.
    ;
    Fauzi N.W.
    ;
    Wahab H.A.
    ;
    Liew S.Y.
    ;
    Awang K.
    ;
    Faculty of Quranic and Sunnah Studies
    ;
    University of Malaya (UM)
    ;
    Universiti Sains Islam Malaysia (USIM)
    ;
    Universiti Sains Malaysia (USM)
    Dengue fever is one of major health problem around the world including Malaysia. It is caused by the arthropode-borne flavivirus and transmitted by the bite of the Aedes aegypti or Aedes albopictus mosquito infected with one of the four dengue virus serotypes (DENV-1, DENV-2, DENV-3, or DENV-4). In this study, a screening exercise of various Malaysian medicinal plants showed that the extracts of Lawsonia inermis, Dryobalanops aromatica, Punica granatum, Zizyphus jujuba Lam. and Zingiber zerumbet exhibited potent inhibitory activity against NS2B-NS3 serine protease. The methanol extracts of Dryobalanops aromatica showed inhibition of 99.70 % at concentration of 200 �g/mL with IC50 value of 0.30 � 0.16 �g/mL. � 2019, Malaysian Society for Parasitology. All rights reserved.