Publication: Dengue protease inhibition activity of selected malaysian medicinal herbs
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Date
2019
Journal Title
Journal ISSN
Volume Title
Publisher
Malaysian Society for Parasitology
Abstract
Dengue fever is one of major health problem around the world including Malaysia. It is caused by the arthropode-borne flavivirus and transmitted by the bite of the Aedes aegypti or Aedes albopictus mosquito infected with one of the four dengue virus serotypes (DENV-1, DENV-2, DENV-3, or DENV-4). In this study, a screening exercise of various Malaysian medicinal plants showed that the extracts of Lawsonia inermis, Dryobalanops aromatica, Punica granatum, Zizyphus jujuba Lam. and Zingiber zerumbet exhibited potent inhibitory activity against NS2B-NS3 serine protease. The methanol extracts of Dryobalanops aromatica showed inhibition of 99.70 % at concentration of 200 �g/mL with IC50 value of 0.30 � 0.16 �g/mL. � 2019, Malaysian Society for Parasitology. All rights reserved.
Description
Tropical Biomedicine 36(2): 357–366 (2019)