Nowadays, research and production of new food products based on genetic engineering technology are carried out to give benefit to the community. However, the production of food products through this technology has raised concerns in the determination of the legal status and the safety of the food products to be eaten by the consumer. Therefore, this article discusses genetically modified food (GMF) in the concept of halalan toyyiban based on the evaluation of maqasid hifz an nafs. This article uses qualitative design through the documentation study method by comparing and analyzing important information from selected sources such as al-Quran, fiqh books, scientific articles, fatwas, and journals from previous research. The results obtained showed that the GMF products are considered to meet the halalan toyyiban concept if the products follow the six principles in the concept which are halal, healthy, accepted by fitrah, safe, clean, and free from syubhah. This study also found that GMF products can be evaluated through three main maslahah (benefit) in maqasid syariah which is dharuriyyat (necessity), hajiyyat (will), and tahsiniyyat (perfection).