Scopus

Permanent URI for this collection

https://oarep.usim.edu.my/handle/123456789/78

Browse

Browsing Scopus by Subject "2-hydroxyethyl cellulose"

Now showing 1 - 1 of 1
  • No Thumbnail Available
    Some of the metrics are blocked by your 
    consent settings
    Publication
    Development Of Cellulose-based Films Containing Salicylic Acid For Wound Dressing Applications: Fabrication, Properties And In Vitro Assessment
    (Sage Journals Home, 2024)
    Mohd Ibnu Haikal Ahmad Sohaimy
    ;
    Muhammad Amir Amzar Ismail
    ;
    Azwani Sofia Ahmad Khiar 
    ;
    Norizah Mhd Sarbon
    ;
    Nora Salina Md Salim
    ;
    Hanis Nadia Yahya
    ;
    Mohd Ikmar Nizam Mohamad Isa
    A wound dressing is important to ensure an efficient healing process while protecting the wound area. This research study combined 2-hydroxyethyl cellulose (2HEC)—an etherified cellulose derivative with salicylic acid (SA) to develop a single layer and investigate the 2HEC viability as wound dressing material. Nine different samples with different compositions of SA, from 5 wt.% to 40 wt.% (with an interval of 5 wt.%) and one control sample without adding SA were prepared via the solution casting method. The 2HEC-SA films were studied regarding the effects of SA composition on antimicrobial properties (Staphylococcus aureus) via the well-diffusion method. Additionally, degradability, mechanical properties, X-ray diffraction (XRD), and Fourier transform infrared (FTIR) of 2HEC-SA films have also been tested. The strongest antimicrobial effect of 2HEC-SA film was obtained at 40 wt.% with a 16 mm inhibition zone diameter. There was a noticeable decreasing weight loss pattern in the degradation test and the tensile strength of 2HEC-SA film when the composition of salicylic acid is increased. 2HEC-SA film changes phases from amorphous to crystalline starting at 25 wt.% of salicylic acid as seen through XRD, while FTIR shows that complexation of 2HEC and salicylic acid occurred at 1050 cm−1.
      8  1