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Anthelmintic Activity of Goat's Milk: Transmission Electron Micrographic Evidence

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dc.contributor.authorOmaima Adil Najmen_US
dc.contributor.authorFaizul Helmi Addnanen_US
dc.contributor.authorMohamed Adel Elkadien_US
dc.contributor.authorWan Omar Abdullahen_US
dc.contributor.authorNur Fariha Binti Mohd Manzoren_US
dc.contributor.authorNoor Amiza Zainal Abidinen_US
dc.contributor.authorFadlul Azim Fauzi Bin Mansuren_US
dc.date.accessioned2024-05-28T04:20:58Z
dc.date.available2024-05-28T04:20:58Z
dc.date.issued2018
dc.descriptionVolume-1 Issue-03en_US
dc.description.abstractUsing the canine hookworm Ancylostoma caninum as model we aimed to investigate the anthelmintic activity of goat's milk in vitro by describing in detail the nature of damage taking place cross sectionally in the worm cuticle after exposure to goat's milk through careful observation by transmission electron microscope (TEM). Adult worms were obtained from routine culling of unwanted dogs from Selayang Municipal Council (MPS) animal detention center, Rawang, Malaysia. Fresh raw goat's milk was used. Worms were cut into 1mm3 slices, fixed in 4% glutaraldehyde, washed with 0.1sodium cacodylate buffer, post fixed in 1% osmium tetroxide, washed again in 1%sodium cacodylate buffer, dehydrated in acetone, embedded in resin, polymerized, ultrathin cross section cut and stained with uranyl acetate before being viewed under transmission electron microscope. Goat's milk resulted in worm cuticular damage in the form of irregularity and significant thinning similarly seen with cysteine proteinases mediated damage. Internal hypodermic changes were also observed in the form of mitochondrial degeneration which appeared as large vacuoles similarly seen in albendazole affected worms. Understanding anthelmintic mechanism through transmission electron micrography has provided critical information in developing novel therapies from natural products. It also provides basis for the consumption of goat's milk as functional food for parasitic worm control.en_US
dc.identifier.citationAnthelmintic Activity of Goat's Milk: Transmission Electron Micrographic Evidenceen_US
dc.identifier.doi10.36348/sijcms.2018.v01i03.001
dc.identifier.epage81
dc.identifier.issn2616-8669
dc.identifier.issue3
dc.identifier.spage77
dc.identifier.urihttps://saudijournals.com/journal-details/sijcms/60/493
dc.identifier.urihttps://oarep.usim.edu.my/handle/123456789/5232
dc.identifier.volume1
dc.language.isoenen_US
dc.publisherScholars Middle East Publisheren_US
dc.relation.ispartofScholars International Journal of Chemistry and Material Sciencesen_US
dc.subjectmilk, goat's milk, Ancylostoma caninum, albendazole, anthelmintic, TEMen_US
dc.titleAnthelmintic Activity of Goat's Milk: Transmission Electron Micrographic Evidenceen_US
dc.typeArticleen_US
dspace.entity.typePublication

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