Publication: Date palm fruit (var. Ajwa) promotes proliferation of human bone marrow mesenchymal stem cells: potential natural booster for endogenous stem cells growth
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Date
2020
Journal Title
Journal ISSN
Volume Title
Publisher
International Society for Horticultural Science (ISHS)
Abstract
Objective – Maintenance of bone marrow derived mesenchymal stem cells (BMMSC) numbers is important to preserve the balance required for normal tissue regeneration. ‘Ajwa’ date palm fruit, a popular Middle Eastern food, is known for its superior nutrition and medicinal properties. However, the direct effect of ‘Ajwa’ dates on stem cell biology remains unclear. This study aims to investigate the potential effect of ‘Ajwa’ date palm fruit on BMMSC proliferation. Materials and methods – BMMSC were treated with different concentrations of aqueous extract of ‘Ajwa’ date palm fruit (mg mL-1). Proliferation, morphology, surface markers and gene expression of BMMSC were evaluated after the treatment. Results and discussion – ‘Ajwa’ date palm fruit significantly enhanced BMMSC proliferation and retained the stemness of BMMSC. Quantitative gene expression analysis demonstrated significant increase of proliferation related genes; β-Catenin, C-Myc and HGF and lower expression of apoptotic genes; BAX and Caspase-3 and senescence-related gene, p21. Conclusion – These findings suggest the potential effect of ‘Ajwa’ date palm fruit as stem cell nutrition in the preservation of endogenous BMMSC for tissue regeneration.
Description
Volume: 75 Issue : 4 (page: 161-165)
Keywords
Phoenix dactylifera L., gene expression, nutrition, stem cell growth
Citation
Masniza, M.L., Zetty Nadia, M.Z., Nur Syahrina, R., Hayati, A.R., Asral Wirda, A.A., Fadlul Azim Fauzi, M. and Nur Fariha, M.M. (2020). Date palm fruit (var. Ajwa) promotes proliferation of human bone marrow mesenchymal stem cells: potential natural booster for endogenous stem cells growth. Fruits 75(4), 161-169. DOI: 10.17660/th2020/75.4.3