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Date palm fruit (var. Ajwa) promotes proliferation of human bone marrow mesenchymal stem cells: potential natural booster for endogenous stem cells growth

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dc.contributor.authorM.L. Masnizaen_US
dc.contributor.authorZetty Nadia Mohd Zainen_US
dc.contributor.authorR. Nur Syahrinaen_US
dc.contributor.authorA.R. Hayatien_US
dc.contributor.authorA.A. Asral Wirdaen_US
dc.contributor.authorM. Fadlul Azim Fauzien_US
dc.contributor.authorM.M. Nur Farihaen_US
dc.date.accessioned2024-05-27T14:50:20Z
dc.date.available2024-05-27T14:50:20Z
dc.date.issued2020
dc.date.submitted2021-2-10
dc.descriptionVolume: 75 Issue : 4 (page: 161-165)en_US
dc.description.abstractObjective – Maintenance of bone marrow derived mesenchymal stem cells (BMMSC) numbers is important to preserve the balance required for normal tissue regeneration. ‘Ajwa’ date palm fruit, a popular Middle Eastern food, is known for its superior nutrition and medicinal properties. However, the direct effect of ‘Ajwa’ dates on stem cell biology remains unclear. This study aims to investigate the potential effect of ‘Ajwa’ date palm fruit on BMMSC proliferation. Materials and methods – BMMSC were treated with different concentrations of aqueous extract of ‘Ajwa’ date palm fruit (mg mL-1). Proliferation, morphology, surface markers and gene expression of BMMSC were evaluated after the treatment. Results and discussion – ‘Ajwa’ date palm fruit significantly enhanced BMMSC proliferation and retained the stemness of BMMSC. Quantitative gene expression analysis demonstrated significant increase of proliferation related genes; β-Catenin, C-Myc and HGF and lower expression of apoptotic genes; BAX and Caspase-3 and senescence-related gene, p21. Conclusion – These findings suggest the potential effect of ‘Ajwa’ date palm fruit as stem cell nutrition in the preservation of endogenous BMMSC for tissue regeneration.en_US
dc.identifier.citationMasniza, M.L., Zetty Nadia, M.Z., Nur Syahrina, R., Hayati, A.R., Asral Wirda, A.A., Fadlul Azim Fauzi, M. and Nur Fariha, M.M. (2020). Date palm fruit (var. Ajwa) promotes proliferation of human bone marrow mesenchymal stem cells: potential natural booster for endogenous stem cells growth. Fruits 75(4), 161-169. DOI: 10.17660/th2020/75.4.3en_US
dc.identifier.doi10.17660/th2020/75.4.3
dc.identifier.epage169
dc.identifier.issn1625-967X
dc.identifier.issue4
dc.identifier.spage161
dc.identifier.urihttps://www.pubhort.org/fruits/75/4/3/index.htm
dc.identifier.urihttps://oarep.usim.edu.my/handle/123456789/3844
dc.identifier.volume75
dc.language.isoen_USen_US
dc.publisherInternational Society for Horticultural Science (ISHS)en_US
dc.relation.ispartofFruits, The International Journal of Tropical and Subtropical Horticultureen_US
dc.subjectPhoenix dactylifera L., gene expression, nutrition, stem cell growthen_US
dc.titleDate palm fruit (var. Ajwa) promotes proliferation of human bone marrow mesenchymal stem cells: potential natural booster for endogenous stem cells growthen_US
dc.typeArticleen_US
dspace.entity.typePublication

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