Publication: Gut bacteria characteristic of the infant microbiota down-regulate inflammatory transcriptional responses in HT-29 cells
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Date
2020
Journal Title
Journal ISSN
Volume Title
Publisher
Academic Press
Abstract
Immuno-modulatory effects of infant gut bacteria were tested on poly(I:C) stimulated HT-29 intestinal epithelial cells. Blautia producta, Bacteroides vulgatus, Bacteroides fragilis and Bacteroides thetaiotaomicron decreased transcription of poly(I:C)-induced inflammatory genes. Modulation of basal level and poly(I:C)-induced IL-8 secretion varied between bacterial species, and between heat treated and non-heat treated bacterial cells.
Description
Anaerobe
Volume 61, February 2020, 102112
Keywords
Bacteroides, Blautia, HT-29, poly(I:C), Ruminococcus