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Antibacterial Activity of Bioactive Compound in Salvadora persica (Chewing Stick) Against Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans

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dc.contributor.authorHaslinda Ramlien_US
dc.contributor.authorZalina Baharudinen_US
dc.contributor.authorRohazila Mohamad Hanafiahen_US
dc.date.accessioned2024-05-28T06:02:07Z
dc.date.available2024-05-28T06:02:07Z
dc.date.issued2022
dc.date.submitted2022-7-26
dc.descriptionASM Science Journal, Volume 17, 2022en_US
dc.description.abstractThis study aims to determine the phytochemical properties of Salvadora persica extracts and their antibacterial activities against Gram-negative oral anaerobes which are responsible of periodontitis such as Porphorymonas gingivalis and Aggregatibacter actinomycetemcomitans. Aqueous and ethanolic extracts were prepared using the root powdered stem of S. persica. The phytochemical compounds were determined with Liquid Chromatography-Mass Spectrometry (LC-MS) and Gas Chromatography-Mass Spectrometry (GC-MS). The antibacterial activities were assessed according to the levels of minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC). The S. persica ethanolic and aqueous extracts contained antibacterial compounds such as Octadecenoic acid, methyl ester, n-Hexadecanoic acid and Pentadecanoic acid, 2,6,10,14-tetramethyl-, methylester, 1-(2,2-Dimethylpropanoyl)-L-prolyl-L-prolyl-N,2-dimethylalaninamide and 2-({4- [(Difluoromethyl)sulfanyl]phenyl} amino) benzoic acid, respectively. Both P. gingivalis (0.025 mg/mL) and A. actinomycetemcomitans (0.125 mg/mL) were susceptible to S. persica ethanolic extract. Ethanolic extract preparation has equal antibacterial activity with 0.2% chlorhexidine gluconate solution (p<0.05). Ethanolic extract (0.025-0.125 mg/mL) preparation has comparable require biocompatible testingen_US
dc.identifier.doi10.32802/asmscj.2022.1101
dc.identifier.epage8
dc.identifier.issn2682-8901
dc.identifier.issue2022
dc.identifier.other1209-24
dc.identifier.spage1
dc.identifier.urihttps://www.akademisains.gov.my/asmsj/article/antibacterial-activity-of-bioactive-compound-in-salvadora-persica-chewing-stick-against-porphyromonas-gingivalis-and-aggregatibacter-actinomycetemcomitans/
dc.identifier.urihttps://oarep.usim.edu.my/handle/123456789/6972
dc.identifier.volume17
dc.language.isoenen_US
dc.publisherASM SCIENCE JOURNALen_US
dc.relation.ispartofASM SCIENCE JOURNALen_US
dc.subjectAggregatibacter actinomycetemcomitans; periodontitis; Porphyromonas gingivalis; Salvadora persicaen_US
dc.titleAntibacterial Activity of Bioactive Compound in Salvadora persica (Chewing Stick) Against Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitansen_US
dc.typeArticleen_US
dspace.entity.typePublication

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