Publication: Chronic histiocytic intervillositis in consecutive miscarriages: A potential pitfall in routine examination of conceptus
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Date
2020-12
Journal Title
Journal ISSN
Volume Title
Publisher
Academy of Medicine Malaysia
Abstract
Introduction: Chronic histiocytic intervillositis (CHI) is a rare placental lesion strongly associated
with recurrent miscarriages and fetal losses. It requires histopathological diagnosis and can only be
made after delivery of the products of conception (POC). We describe a case of CHI in a 41-yearold lady with a 16-year history of thirteen recurrent consecutive first trimester miscarriages. Case
report: The patient is a 41-year-old lady who suffered first trimester miscarriages in all her thirteen
pregnancies. The relevant clinical investigations revealed neither significant nor helpful findings
in determining the cause of recurrent miscarriages. Histological findings in each except one of the
submitted conceptual tissue showed similar features of histiocytic aggregates primarily within the
intervillous spaces, a characteristic description of CHI. One of the samples showed degenerative
changes. Discussion: Practicing pathologists are not familiar with the histological features of CHI
and this may be a potential pitfall in routine examination of POCs. Recognising this entity allows
for accurate diagnosis and hence better management. The aetiology remains unclear, although an
immunopathological basis are being explored.
Description
The Malaysian Journal of Pathology
2020 Dec;42(3):439-444.
Keywords
Recurrent miscarriages,, chronic histiocytic intervillositis, massive chronic intervillositis, chronic intervillositis of unknown aetiology