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Chronic histiocytic intervillositis in consecutive miscarriages: A potential pitfall in routine examination of conceptus

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dc.contributor.authorSiti Khadijah Mohd Fuaden_US
dc.contributor.authorNazifah Adznanen_US
dc.contributor.authorAbd Rahman Hayatien_US
dc.contributor.authorVikneswaran Virasamyen_US
dc.contributor.authorNur Syahrina Binti Rahimen_US
dc.date.accessioned2024-05-27T14:34:22Z
dc.date.available2024-05-27T14:34:22Z
dc.date.issued2020-12
dc.date.submitted2021-2-9
dc.descriptionThe Malaysian Journal of Pathology 2020 Dec;42(3):439-444.en_US
dc.description.abstractIntroduction: Chronic histiocytic intervillositis (CHI) is a rare placental lesion strongly associated with recurrent miscarriages and fetal losses. It requires histopathological diagnosis and can only be made after delivery of the products of conception (POC). We describe a case of CHI in a 41-yearold lady with a 16-year history of thirteen recurrent consecutive first trimester miscarriages. Case report: The patient is a 41-year-old lady who suffered first trimester miscarriages in all her thirteen pregnancies. The relevant clinical investigations revealed neither significant nor helpful findings in determining the cause of recurrent miscarriages. Histological findings in each except one of the submitted conceptual tissue showed similar features of histiocytic aggregates primarily within the intervillous spaces, a characteristic description of CHI. One of the samples showed degenerative changes. Discussion: Practicing pathologists are not familiar with the histological features of CHI and this may be a potential pitfall in routine examination of POCs. Recognising this entity allows for accurate diagnosis and hence better management. The aetiology remains unclear, although an immunopathological basis are being explored.en_US
dc.identifier.epage444
dc.identifier.issn0126-8635
dc.identifier.issue42
dc.identifier.other588-38
dc.identifier.spage439
dc.identifier.urihttp://www.mjpath.org.my/2020/v42n3
dc.identifier.urihttps://oarep.usim.edu.my/handle/123456789/3178
dc.identifier.volume3
dc.language.isoenen_US
dc.publisherAcademy of Medicine Malaysiaen_US
dc.relation.ispartofMalaysian Journal of Pathologyen_US
dc.subjectRecurrent miscarriages,en_US
dc.subjectchronic histiocytic intervillositisen_US
dc.subjectmassive chronic intervillositisen_US
dc.subjectchronic intervillositis of unknown aetiologyen_US
dc.titleChronic histiocytic intervillositis in consecutive miscarriages: A potential pitfall in routine examination of conceptusen_US
dc.typeArticleen_US
dspace.entity.typePublication

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