Publication: Necrotizing autoimmune myopathy: A case series
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Date
2020
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Volume Title
Publisher
Universiti Putra Malaysia Press
Abstract
Necrotizing autoimmune myopathy (NAM) is considered a new subgroup of a rare autoimmune idiopathic inflammatory myopathies. Classically, NAM presented with sub-acute onset of proximal muscle loss of power with raised creatinine kinase and characteristic muscle biopsy showing muscle necrosis and regeneration with little inflammation. Statin use, connective tissue diseases, malignancy and HIV infection are the identified risk factors for NAM. The autoantibodies expected to be presented in NAM are anti-signal recognition particle (SRP) and anti-hydroxymethylglutaryl-coenzyme A reductase (anti-HMGCR) antibodies. In this article, we present three cases of NAM with different risk factors and autoantibodies which we believe to have impact on the clinical course and outcome of our patients. � 2020 UPM Press. All rights reserved.
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Keywords
Antibodies, Idiopathic Inflammatory Myopathies, Necrotizing Autoimmune Myopathy