Publication: Multiple Sclerosis- Challenges In Diagnosis.
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Date
2022
Journal Title
Journal ISSN
Volume Title
Publisher
USIM Press, Universiti Sains Islam Malaysia
Abstract
Multiple Sclerosis is an inflammatory demyelinating disease that affects the central nervous system, and is uncommon among the Asian population. It can present with a variety of symptoms, depending on the location of the demyelinating plaques, which could also potentially mimic a range of neurological and non-neurological disorders. We report a 24-year-old woman who presented with recurrent non-specific lower limb numbness, without any other neurological symptoms or signs. The symptoms were presumed to be nonspecific, but they re-occurred eight months later, leading to a more extensive investigation, including whole spine and brain MRI. The MRI showed multiple white matter lesions that are hyperintense on T2W/FLAIR, seen at the right corona radiata, bilateral parietal lobes, right periventricular region and spinal cord, with a simultaneous presence of gadolinium-enhancing and nonenhancing lesions, fulfilling 2017 Mc Donald’s diagnostic criteria for multiple sclerosis. After the careful exclusion of differential diagnoses, she was given pulsed IV methylprednisolone for 5 days, followed by oral teriflunomide. She improved partially, and at 2 months following discharge, she was tolerating the medication well with no further relapses.
Description
Volume: 8 (page: 4–7)
Keywords
multiple sclerosis; numbness; challenge; diagnosis; non-specific
Citation
Mohammad Kazmin, N. E., Tan, H. J., Solehan, H. M., Fatimah Zanirah, Tan, W. M., A Bakar, M. F., & Samad, S. Z. (2022). Multiple Sclerosis – Challenges in Diagnosis. Malaysian Journal of Science Health & Technology, 8, 4–7. https://doi.org/10.33102/2022271