Publication: Liver Allograft Biopsies: Experience in Hospital Selayang
No Thumbnail Available
Date
2011
Journal Title
Journal ISSN
Volume Title
Publisher
College of Pathologists, Academy of Medicine Malaysia
Abstract
Introduction: Liver biopsies are important to document any allograft rejection in liver transplantation.
As one of the main centres providing liver transplant services, we are fortunate to experience
dealing with liver allograft biopsies. Here, we briefl y describe our experience over a 7-year period.
Materials and Methods: All reports of liver allograft biopsies performed from January 2004 to
December 2010 in Hospital Selayang along with the relevant clinicopathological data were retrieved
from the Department of Pathology archives using Cerner Pathnet Application. Results: There were
29 biopsies done from 18 patients aged between 19 months to 47 years old. Eleven of them were
from males and 7 were female patients. There were 10 Malays, 5 were Chinese and 3 were Indians.
Biliary atresia, Tyrosinaemia, Alagille’s syndrome and fulminant liver failure were some of the
earlier indications or aetiologies for the liver transplantation. Most of them showed abnormal liver
enzymes prior to allograft biopsy. The biopsies were evaluated using Banff scheme for liver allograft
rejection. Ten (34.5%) of the cases showed acute rejection, 2 of the cases was indeterminate and
another 2 cases showed chronic rejection. Fourteen (48.3%) of the cases showed no evidence of
rejection. Drug induced injury, chronic biliary outfl ow obstruction, vanishing bile duct syndrome and
chronic hepatitis were among the histopathological changes found in the allograft biopsies of these
14 cases. Conclusion: Liver biopsy is useful to evaluate graft dysfunction and to confi rm clinically
suspected rejection. Adequate interpretation is dependent on adequacy of sampling, knowledge of
differential diagnoses, clinical aspects of transplant hepatology and also close interaction with the
clinical team.
Description
Poster
Keywords
liver allograft biopsy, liver transplant, rejection
Citation
MS, Noor & MM, Noor & NS, NikMalihan & Rahim, Nur & MY, NorFadzilah. (2011). Liver Allograft Biopsies: Experience in Hospital Selayang. The Malaysian journal of pathology. 33. 142.