In the title compound, C22H24N4O 2S2, the two thiourea segments of the side-arm groups are inclined at a dihedral angle of 73.09 (9)°. The central cyclohexane bridge adopts a chair conformation. The molecule is stabilized by N-H⋯O intramolecular hydrogen bonds forming S(6) rings, and N-H⋯O and N-H⋯S intermolecular hydrogen bonds forming infinite chains developing parallel to the b axis.

Medical experiments on humans are among the most dangerous that a person can be exposed to, especially in light of the tremendous scientific and technological progress that the health field is witnessing, which harms the human right to health safety, the problem of the study stems from the jurisprudential difference about the legality of medical experiments on the human body According to the traditional view, there is no legitimacy for medical experiments when they are stripped of the intention of treatment and cure, and therefore the doctor is asked about errors in the medical experiments that he conducts for the purposes of scientific research, while the modern jurisprudential view legitimizes medical experiments whenever they are for the purposes of healing, treatment and scientific research if they are abstract From the material character, and this requires the approval of rules and regulations for these experiments through the approval of legislation for this type of experiments, similar to many developed countries, such as the French law, and from this problem the objectives of the study are reflected, which is to clarify what is meant by non-therapeutic medical experiments, and to discuss the legitimacy of medical experiments other than Curative treatment on the human body, as well as clarifying the legislative position on non-therapeutic medical experiences on the human body, as well as explaining the responsibility for To violate the rules for conducting these experiments, and to facilitate the achievement of the objectives of the study, its approach is inductive approach based on extrapolating and analyzing texts, in order to reach effective solutions to the study problem.

Teaching practicum is an essential part of teacher-training that provides real classroom engagement for a beginner teacher. It is considered as one of the most critical components of teacher preparation with the greatest impact on teacher quality (Mtika, 2011; Zeichner, 2010; Graham, 2006; Tang, 2003) and is significant for the development of their pedagogical skills (Kauffman, 1992). The sudden upsurge of the Covid -19 infections around the world in the first quarter of 2020, witnessed massive closure of schools worldwide in order to contain the spread of the pandemic. This unexpected turn of events had flipped the more traditional face-to-face method of teaching and learning into distance learning that requires 21st. Century technology and skills. This paper explores the experience of a group of trainee teachers from an institute of higher learning in Malaysia, at managing this unprecedented challenge in delivering education remotely via technology. Data were collected from interviews and supplemental written records in the form of lesson plans, teaching evidence, and online tools employed for teaching and learning. The findings show that the trainee teachers undergo varied and often challenging experiences in ensuring the continuity of curriculum-based education and the students’ progress in learning. Their successes in delivering the lessons amidst the novel encounters are the epitome of resilient and flexible teachers in the making.

The study aims to identify possible ways and methods of guiding investments and selecting projects. It must undergo in-depth studies to prove its feasibility in development. There should also be a set of legitimate, economic, and social criteria for preference between investment projects and economic activities shall be arranged based on the priorities of the Islamic interest (Maslahah). Then such projects shall have criteria and foundations on which to evaluate and measure development performance and social impact to achieve inclusive and sustainable development of our Islamic communities. The researcher concluded that the system of investment priorities should be adhered to in all investment policies and processes and that social responsibility should be activated as one of the most important factors for enhancing development performance. The study also recommends a vigorous pursuit toward creating new standards and indicators that enhance the developmental role of Islamic institutions.

Purpose: This study aims to provide a comprehensive bibliometric analysis of the literature on unemployment Takaful, job loss protection, and unemployment insurance from 2012 to 2023, illuminating trends, key contributions, and focal areas within the realm of insurance. Design/Methodology/Approach: Using the Scopus database, a systematic search was conducted using the keywords "unemployment takaful", "job loss protection", "unemployment insurance", and "insurance". Publications were then analyzed to determine their distribution by year, contributing authors and institutions, citation frequency, keyword co-occurrence, and more. Findings: The period 2012 to 2023 witnessed a significant increase in research concerning unemployment protection mechanisms. "Unemployment Insurance" emerges as a central topic, underscoring the focus on mechanisms to support individuals during joblessness, with major contributions from Friedman, 2014. Geographic distribution indicated a pronounced focus in United States (USA). Research Limitations/Implications: The analysis is constrained by the scope of the Scopus database and the selected keywords, potentially omitting relevant studies indexed elsewhere or under different terms. The findings underscore the need for interdisciplinary approaches in studying unemployment protection mechanisms and suggest potential avenues for future research. Practical Implications: The findings of this study showed there is a gap of the research in takaful discussing on the issues of employment safety. Most of the research conducted in developed nations and insurance company. This is suggested that, takaful should explored the are of unemployment takaful by providing an alternative for Muslim customers. Originality/Value: This bibliometric analysis presents a holistic overview of the literature landscape on unemployment protection mechanisms during a pivotal period. It serves as a foundational reference for researchers, policymakers, and industry stakeholders keen on understanding the evolution, trends, and gaps in this field.

A Maturity Model (MM) is essential for laboratories aiming to improve and compete globally. Despite being accredited for over 20 years, some laboratories lack evidence of system maturity necessary for international competitiveness. A higher maturity level indicates a robust quality management system, leading to improved efficiency, accuracy, and customer satisfaction, while also assuring stakeholders, such as customers and regulatory bodies, of the laboratory's commitment to continuous improvement. The MM is designed to assess the success of laboratory processes, management styles, and the development of quality management practices, based on the 4M model (Manpower, Method, Machine, Material). The MM was developed using Analytes Accurate Certain Score (AACS) for the ten most common tests and System Maturity Scores (SMS), which incorporate proficiency testing and audit scores over two accreditation cycles (six years). While the model identifies inefficiencies, it helps organizations pinpoint areas of improvement and devise strategies to enhance their operations. This study applied the MM to a commercial laboratory, ABC (anonymized), accredited since the early 1990s and having undergone eight assessment cycles. The laboratory was found to be at a “leading” maturity level with a score above 80%, although improvements are still needed. Key areas for improvement include: 1) **Manpower**: maintaining competent staff by adjusting management strategies, 2) **Method**: validating all in-house methods according to Analytical Laboratory Accreditation Criteria Committee (ALACC) guidelines, 3) **Machine**: applying good laboratory practices (GLP) for equipment sharing, especially for specific analytes, and 4) **Material**: ensuring metrologically traceable reference materials and proficiency testing for all analytes. These improvements will help the laboratory further enhance its global competitiveness.

Despite spending a significant number of resources and years developing a medical system, Patients with underlying comorbidities who have SARS-nCoV-2 carry a heavy financial burden that necessitates significant medical expenditures and resources for patient care. Clinical management cost uncertainty paralyzes the healthcare system and causes deficits in annual national budgets. This research will be focusing the necessary steps in developing the protocol. Overall, this article will include intervention logic mapping, questionnaires, recorded consultations, in-depth interviews, focus group discussions, and contextual data recording will be used as methods. The best effective AI-based technique for medical expense prediction and estimation for COVID-19 patients with comorbidities was identified. Regarding medical perspective and user acceptance, a better grasp of the issues and barriers confronting Malaysia's healthcare system. Deep learning techniques created a CNN-based model for predicting medical costs. Validation of the proposed model using real-world data and demonstration of its capacity to appropriately anticipate expenses. Using a relevant performance indicator such as RMSE, compare the constructed model to existing cost prediction approaches. Insights about the economic impact of COVID-19 on patients with comorbidities and healthcare practitioners in Malaysia. This research on the economic impact of COVID-19 on patients with comorbidities and healthcare practitioners, along with the development of a CNN-based cost prediction model, has significant implications for healthcare management, policy-making, and AI advancement in healthcare. The findings will inform more efficient resource allocation, guide public health policies, and contribute to the ongoing development of AI applications in healthcare.

Leptospirosis is an endemic disease worldwide and its incidence is increasing with outbreaks and mortality. It is caused by Leptospires interrogans which are very thin,spiral-shaped, tightly coiled, gram-negative aerobic, spirochetes. It can cause several infection to human including organs such as the kidneys, liver, lungs, heart and the central nervous system. The organism can give rise to several ocular manifestations and when it affect the eyes, it causes Leptospirosisneuroretinitis. The present case illustrated a case of 9 year-old boy succumbed withleptospirosisinfection presenting as neuroretinitis. The unique of the case is that the boy had noobvious systemic manifestation of leptospirosis which caused a challenge to a physician to arrive at the diagnosis. Other important differentials had be entertained namely toxoplasmosis and ocular tuberculosis.,Further management had been discussed until the boy was discharged and being followed up as an outpatient. This is followed by the discussion on leptospirosis neuroretinitis.

Primary cerebral lymphoma in immunocompromised patients is rare and challenging to diagnose. Its presentation can have similarities with other opportunistic diseases like cerebral toxoplasmosis and tuberculoma, to name a few, which may affect the subsequent management. Here, we report a case of a gentleman with human immunodeficiency virus (HIV) who presented with clinical features of fever, confusion, and generalized lethargy. His imaging features mimicked those of central nervous system (CNS) tuberculosis (TB), and he was treated for one. Unfortunately, the patient failed to respond to the antituberculosis treatment and continued to deteriorate eventually succumbing to his illness. Brain histopathology biopsy confirmed the diagnosis of diffuse large B-cell lymphoma. We aim to illustrate the importance of a high index of suspicion with timely action taken whenever the anticipated finding or response to treatment is not observed. Multiple imaging modalities coupled with biochemistry and histopathological investigations should be considered in discriminating competing diagnoses.

This article explores the pivotal roles of attitude and motivation in English language learning, focusing on the unique context of Tahfiz students. Drawing upon scholarly literature, the article explores the definitions, interactions, and influences of these two key factors on language acquisition. By analysing existing studies within the field, the article aims to provide educators and stakeholders with a deeper understanding of the importance of attitude and motivation in supporting students' language learning journeys. The study's novelty lies in its focus on the Tahfiz setting, a context often overlooked in language learning research. Positive attitudes and motivation are crucial for Tahfiz students, as indifference can hinder their efforts and learning progress. By effectively cultivating these factors, educators can significantly impact the success of Tahfiz students in acquiring English as a second language (L2), enabling them to become global Islamic scholars.

Stroke is a global health concern where it has significant economic implications and poses a major challenge to public health systems and society. In combating this issue, scientometric analysis is one of the tools that can be used to discern prevailing trends and gauge the influence of research endeavors. This Scientometric study on embolic stroke was conducted using the narrative review in Web of Science Core Collection (WoS) from 1965 to 2023.Along these lines, the number of articles, citations and countries regarding this issue were determined and the sigma score and cluster of the articles were analyzed using CiteSpace software. A total of 3731 articles were found regarding this issue in WoS. Among the countries that have published papers regarding this issue, The United States of America (USA) has contributed the most (35%). Papers by Hart RG have been cited the most as the number 1, 2 and 3 most cited papers. Most of the Top 10 Most Cited papers were regarding prevention and early treatment of stroke. Out of the major cluster of papers, the top cluster was regarding embolic stroke/platelet study.As stroke is a large topic, we have discovered many significant clusters with shared features through this study, offering a targeted direction for more research and potential advancements in studies connected to stroke.

Purpose: The purpose of this study is to investigate the factors that affect propensity to indebtedness among young working Malays in Malaysia. Individual indebtedness has been a phenomenon in Malaysia especially since the 2008 global financial crisis. Measured by household debt to gross domestic product (GDP), Malaysia experienced high levels of household debt of more than 80% since 2010. Consumption behaviour patterns have revolutionized in recent years where online shopping has been a norm. Online shopping has been made easy by reliable payment gateway including the use of credit card and buy-nowpay-later (BNPL) facilities. Furthermore, there is a constant offer and strong promotion of mega sales on online shopping sites. Design/methodology/approach: In this study, four variables are tested as predictors to propensity to indebtedness. They are money management skills, status consumption, susceptibility to interpersonal influence, and attitudes towards debt. The sample for this study consisted of 324 valid respondents who participated in a survey. The data was collected via online platform and physical. The data was analyzed using the partial least square structural equation modelling (PLS-SEM). Findings: The findings revealed that there is a substantive significant negative relationship between money management skills and attitudes towards debt. Status consumption and susceptibility to interpersonal influence substantively significantly affect attitudes towards debt positively. And attitudes towards debt significantly affects the propensity to indebtedness positively. For mediation, it has been found that attitudes towards debt mediated the relationship between all the three variables (money management skills, status consumption, and susceptibility to interpersonal influence) and propensity to indebtedness. Research limitations/implications: Further research may include socio demographic factors such as parental guide, other consumer behaviour factors such compulsive buying, and other financial factors such as access to credit as predictors to propensity to indebtedness. The research can also be extended to pre-retirement individuals as these people are also quite fragilein facing debt problem as they have short period of time to recover their indebtedness problem before they retire. Practical implications: The results could be used by regulators to control the high level of indebtedness among Malaysians, especially the young people. The government, through relevant agencies, may educate people about the importance of personal financial management and the risks of being over-indebted. Originality/value: The variables used in this study represent financial factors and consumer behaviour factors.

Being motivated is a major factor contributing to student excellence in their studies and success in life. Students face various academic pressures from the education system itself or from environmental factors that can impact their level of motivation to achieve excellence. This study explores achievement motivational levels among university students in Malaysia from the four aspects of gender, race, place of residence and academic performance (CGPA). This survey-type study uses a simple random sampling method involving research subjects comprising 200 students (n=200). The research instrument used is the Achievement Motivation Test (AMT) introduced by Abu Bakar Nordin (1995). Data was analyzed using SPSS Version 26 software. An independent sample t-test analysis was used to identify the differences in achievement motivation levels based on the four aspects mentioned. Overall, the study found no difference in the level of student motivation based on gender (t= 0.254, p> 0.05), race (t= 0.922, p> 0.05), place of residence (t= 1.836, p> 0.05), and academic performance (t=1.623, p> 0.05). However, some differences in motivation levels were found between students with low (M = 2.8) and high (M = 3.0) CGPAs. Thus, it can be concluded that motivational levels have a major role in ensuring student success and excellence. This study can form the basis for designing motivational modules or guidelines in public universities and the Ministry of Education for enhancing student achievement.

Background Abusive head trauma (AHT) is a leading cause of traumatic head injury in young children. This study estimated the annual direct medical cost of managing AHT at a single tertiary care centre in Malaysia. Methods Criteria were set for categorisation of patients as moderate or severe based on resource utilisation. The two methods used for cost computation were (1) cost estimation based on predefined clinical pathways for case management (2) computation of actual costs using patient-level data from retrospective review of all AHT admissions in 2021. Both methods utilised a combination of activity-based and top-down costing according to availability of reference data. Costs are presented in USD. Results Costs for 9 severe and 3 moderate cases in 2021 amounted to $70,532.16, of which 93 % was for severe cases. Cost estimate for moderate cases was $2009.88 while actual costs ranged between $749.37–3115.47 (median $1422.76). Cost estimates of $15,125.76–$17,958.18 for severe cases exceeded actual costs of $2195.57–$13,186.03 (median $7379.40) for severe cases due to shorter-than-expected duration of stay, with only 2 who underwent neurosurgical procedures. Major cost contributors were duration of stay, intensive care, ventilation and neurosurgical procedures. Conclusion Cost comparison utilising predefined treatment standards versus actual patient data which reveals major cost determinants enables refinement of budget allocation. Median medical costs for severe cases which exceeded the monthly income ceilings of low- and middle-income households in Malaysia demonstrate the economic burden of AHT, reinforcing the need to invest in prevention.

Abstract: The major challenge faced by the Halal industry is the shortage of knowledgeable work force thatunderstands syariah requirements and implementing this theoretical knowledge into actual industrial practice.This paper highlights a multi-disciplinary approach towards Halal education, scientific training and services.As a multi-racial country, in Malaysia, one needs not necessarily become a Muslim, in order to be activelyinvolved in the Halal services and production line. Ignorance, confusion or deliberate fraudulent practiceswill consequently result in the presence of adulterants or contaminants in the product, making it Haram orSyubhah with negative consequence on Halal branding. The Halal integrity and values are thus compromised.The Malaysian Standard MS 1500:2009 and the Trade Description Act 2011 are legal guidelines, mandatory forthe acquiring of the Malaysian Halal logo. Understanding the principles and practices ofHalalan andthoyyiban, with hands-on knowledge that meets industrial needs and demand, is necessary to cater for the rapidexpansion of the Halal industry and to achieve compliance. As a niche-comprehensive university, UniversitiSains Islam Malaysia have collaborated with the Halal industry and government agencies in the developmentand implementation of training modules for meat slaughterers, laboratory analysts and those involved in theareas of food, pharmaceutical, cosmetics and consumer goods. The Halal Executive Program with HDC wasdone, to fulfill the needs for trained human resources for the monitoring and surveillance agencies. This holisticinitiative of combining syariah knowledge with technology has benefited the Halal industry, the NGOs,education system and the Muslim communities and consumers. Key words: Multi-disciplinary Halal Assurance Education Capacity building

Digital evidence is now increasingly relevant and becoming a wide-ranging issue, such as crimes committed, the movement of suspects and criminal associates in different forms of crimes for investigation and prosecution. The purpose of this research is to systematically review recent literature relating to the requirement on the admissibility of digital document in court. This qualitative research uses systematic literature review to collect recent related literature, which was then evaluated by adapting deductive and inductive reasoning using the method of content analysis. The data gathered by using comparative research that aims to make comparisons across different two database. The result of the study the basic requirements on accepting the digital document in court. In order to ensure the validity and consistency of the digital evidence submitted to the court, this paper aims to clarify the admissibility of digital evidence in court, and then implement the process by collecting preserved and properly administered. Because digital evidence is continually expanding, the need for certain procedures is important. As a researcher, contributes to the development of knowledge by discuss recent academic writing that can cause more elaborate studies and connected on the issue of the admissibility of digital document in court.

The purpose of this research is to explore case studies based on multiple case study aiming to provide a comprehensive understanding of the waqf accountability practices in Malaysia. Waqf as well as the philanthropic body in Malaysia at this time having a massive development from its first presence in the past. The development generates, among others, especially subject to managing accountability. In Malaysia, the State Islamic Religious Council (SIRCs) is accountable to handle waqf assets given to them. As of recent, there are numbers of study taking into the functioning of the State Islamic Religious Councils in handling the waqf. This critical analysis of waqf is based on 13 states and 1 federal territory in Malaysia. The article is primarily theoretical and conceptual nature. Literature explores the history of the establishment, the law applies, current practices and the accountability practices. The results provide added value to the current research.

Mosquitoes represent the deadliest animal species in tropical regions because they can affect human health. Personal protection which is mosquito repellent has been used since 20th century. Mosquito repellent which contains plant-based ingredients has high demand from consumers since its efficacy is as good as synthetic ones. Citronella genus plants are originally extracted to be used in perfumery, then they were used for ingredients of plant-based mosquito repellents as they have repellent properties. Citronellalbased repellent has an effective dose such as N,N-diethyl-meta-toluamide dose. However, the oil content has high volatility causing it to reduce its efficacy because the oil evaporates. Recently, the structure of citronellal compound has been modified into hydroxycitronellal by adding some functional groups to reduce the release rate, prolong the protection time and improve the stability of the compound. The release rate properties are affected by functional groups and the molar mass of the compounds. This paper presents a summary of recent catalyst and solvent usage during synthesis, characterization and comparison of mosquito repellents.

This is a conceptual article that includes an examination of a literature review on waqf from 2011 to 2021. According to the findings, "Use More" can occur among beneficiaries for various types of waqf and different types of beneficiaries. Donors' characteristics, as well as internal and external aspects of incentive, all contribute to the phrase "donate more." "Share more" refers to information exchange between three parties: the waqf manager/mutawalli, donors, and recipients. Waqf Prosumers encourage donors, in which the same person plays all three roles of Beneficiaries, Donors, and Volunteers in order to disseminate information. The Benefidonor Concept is dependent on the interactions between the three parties. The three parties share common interests in cultivating the quality of growth and change, as evidenced by their same points of view on 'Use more, donate more, and share more.' Furthermore, we discovered that in order for the donor to repeat, accountability and reporting are critical.

The Warwick-Edinburgh Mental Well-Being Scale (WEMWBS) was developed to assess the mental well-being of an individual or population. This study reports the processes of translation, validation and analysis of the reliability of the Malay version of the WEMWBS (WEMWBS-ACREDA). The instrument consists of 20 positively worded items and uses a5-point likert scale. The 14 original items in the WEMWBS were maintained and 6 new items measuring spirituality were added. The adaptation, translation and validation processes for the instrument were performed by four experts in counselling and psychology with Malay and English language competency. The experts used face validity and back translation techniques. A pilot test was conducted to determine the reliability of the new translated version of the WEMWBS-ACREDA and involved 51 randomly selected in-patients at the Cure and Care Clinic. The data were analysed using Cronbach's alpha and the result of 0.91 indicated high reliability. These findings indicate that the translated version of the WEMWBS-ACREDA is reliable and appropriately measures the mental well-being of normal individuals involved in drug abuse in a local setting. Moreover, the new translated version of the WEMWBSACREDA represents a short and convenient psychological tool. However, further studies are recommended to support the findings of this research.